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https://hdl.handle.net/1959.11/48050
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DC Field | Value | Language |
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dc.contributor.author | Ooi, Esther M | en |
dc.contributor.author | Chan, Dick C | en |
dc.contributor.author | Hodson, Leanne | en |
dc.contributor.author | Adiels, Martin | en |
dc.contributor.author | Boren, Jan | en |
dc.contributor.author | Karpe, Fredrik | en |
dc.contributor.author | Fielding, Barbara A | en |
dc.contributor.author | Watts, Gerald F | en |
dc.contributor.author | Barrett, P Hugh R | en |
dc.date.accessioned | 2022-03-09T01:33:26Z | - |
dc.date.available | 2022-03-09T01:33:26Z | - |
dc.date.issued | 2016-08 | - |
dc.identifier.citation | European Journal of Clinical Investigation, 46(8), p. 730-736 | en |
dc.identifier.issn | 1365-2362 | en |
dc.identifier.issn | 0014-2972 | en |
dc.identifier.uri | https://hdl.handle.net/1959.11/48050 | - |
dc.description.abstract | Background <p>Experimental data suggest that apolipoprotein (apo) C-II and C-III regulate triglyceride-rich lipoprotein (TRL) metabolism, but there are limited studies in humans. We investigated the metabolic associations of TRLs with apoC-II and apoC-III concentrations and kinetics in women.</p> Material and methods <p>The kinetics of plasma apoC-II, apoC-III and very low-density lipoprotein (VLDL) apoB-100 and triglycerides were measured in the postabsorptive state using stable isotopic techniques and compartmental modelling in 60 women with wide-ranging body mass index (19·5-32·9 kg/m<sup>2</sup>).</p> Results <p>Plasma apoC-II and apoC-III concentrations were positively associated with the concentrations of plasma triglycerides, VLDL<sub>1</sub>- and VLDL<sub>2</sub>-apoB-100 and triglyceride (all <i>P</i> < 0·05). ApoC-II production rate (PR) was positively associated with VLDL<sub>1</sub>-apoB-100 concentration, VLDL<sub>1</sub> triglyceride concentration and VLDL<sub>1</sub> triglyceride PR, while apoC-II fractional catabolic rate (FCR) was positively associated with VLDL<sub>1</sub> triglyceride FCR (all <i>P</i> < 0·05). No significant associations were observed between apoC-II and VLDL<sub>2</sub> apoB-100 or triglyceride kinetics. ApoC-III PR, but not FCR, was positively associated with VLDL<sub>1</sub> triglyceride, and VLDL<sub>2</sub>-apoB-100 and triglyceride concentrations (all <i>P</i> < 0·05). No significant associations were observed between apoC-III and VLDL-apoB-100 and triglyceride kinetics. In multivariable analysis, including homoeostasis model assessment score, menopausal status and obesity, apoC-II concentration was significantly associated with plasma triglyceride, VLDL<sub>1</sub>-apoB-100 and VLDL<sub>1</sub> triglyceride concentrations and PR. Using the same multivariable analysis, apoC-III was significantly associated with plasma triglyceride and VLDL<sub>1</sub>- and VLDL<sub>2</sub>-apoB-100 and triglyceride concentrations and FCR.</p> Conclusions <p>In women, plasma apoC-II and apoC-III concentrations are regulated by their respective PR and are significant, independent determinants of the kinetics and plasma concentrations of TRLs.</p> | en |
dc.language | en | en |
dc.publisher | Wiley-Blackwell Publishing Ltd | en |
dc.relation.ispartof | European Journal of Clinical Investigation | en |
dc.title | Triglyceride-rich lipoprotein metabolism in women: roles of apoC-II and apoC-III | en |
dc.type | Journal Article | en |
dc.identifier.doi | 10.1111/eci.12657 | en |
dc.identifier.pmid | 27378472 | en |
local.contributor.firstname | Esther M | en |
local.contributor.firstname | Dick C | en |
local.contributor.firstname | Leanne | en |
local.contributor.firstname | Martin | en |
local.contributor.firstname | Jan | en |
local.contributor.firstname | Fredrik | en |
local.contributor.firstname | Barbara A | en |
local.contributor.firstname | Gerald F | en |
local.contributor.firstname | P Hugh R | en |
local.profile.school | Faculty of Medicine and Health | en |
local.profile.email | pbarret6@une.edu.au | en |
local.output.category | C1 | en |
local.record.place | au | en |
local.record.institution | University of New England | en |
local.publisher.place | United Kingdom | en |
local.format.startpage | 730 | en |
local.format.endpage | 736 | en |
local.identifier.scopusid | 84979515549 | en |
local.peerreviewed | Yes | en |
local.identifier.volume | 46 | en |
local.identifier.issue | 8 | en |
local.title.subtitle | roles of apoC-II and apoC-III | en |
local.contributor.lastname | Ooi | en |
local.contributor.lastname | Chan | en |
local.contributor.lastname | Hodson | en |
local.contributor.lastname | Adiels | en |
local.contributor.lastname | Boren | en |
local.contributor.lastname | Karpe | en |
local.contributor.lastname | Fielding | en |
local.contributor.lastname | Watts | en |
local.contributor.lastname | Barrett | en |
dc.identifier.staff | une-id:pbarret6 | en |
local.profile.orcid | 0000-0003-3223-6125 | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.identifier.unepublicationid | une:1959.11/48050 | en |
local.date.onlineversion | 2016-07-05 | - |
dc.identifier.academiclevel | Academic | en |
dc.identifier.academiclevel | Academic | en |
dc.identifier.academiclevel | Academic | en |
dc.identifier.academiclevel | Academic | en |
dc.identifier.academiclevel | Academic | en |
dc.identifier.academiclevel | Academic | en |
dc.identifier.academiclevel | Academic | en |
dc.identifier.academiclevel | Academic | en |
dc.identifier.academiclevel | Academic | en |
local.title.maintitle | Triglyceride-rich lipoprotein metabolism in women | en |
local.relation.fundingsourcenote | EMO is a Heart Foundation Future Leader Fellow (Award ID:100422). DCC and PHRB are Career Development and Senior Research Fellows of the National Health and Medical Research Council of Australia, respectively. LH is a British Heart Foundation Intermediate Fellow in Basic Science. | en |
local.output.categorydescription | C1 Refereed Article in a Scholarly Journal | en |
local.search.author | Ooi, Esther M | en |
local.search.author | Chan, Dick C | en |
local.search.author | Hodson, Leanne | en |
local.search.author | Adiels, Martin | en |
local.search.author | Boren, Jan | en |
local.search.author | Karpe, Fredrik | en |
local.search.author | Fielding, Barbara A | en |
local.search.author | Watts, Gerald F | en |
local.search.author | Barrett, P Hugh R | en |
local.uneassociation | Unknown | en |
local.atsiresearch | No | en |
local.sensitive.cultural | No | en |
local.identifier.wosid | 000383521000007 | en |
local.year.available | 2016 | en |
local.year.published | 2016 | en |
local.fileurl.closedpublished | https://rune.une.edu.au/web/retrieve/e31cdfed-3cbe-49ef-9cf8-b93e5f70300e | en |
local.subject.for2020 | 320101 Cardiology (incl. cardiovascular diseases) | en |
local.subject.seo2020 | 200105 Treatment of human diseases and conditions | en |
Appears in Collections: | Journal Article |
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