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https://hdl.handle.net/1959.11/48017
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DC Field | Value | Language |
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dc.contributor.author | Chan, Dick C | en |
dc.contributor.author | Barrett, P Hugh R | en |
dc.contributor.author | Watts, Gerald F | en |
dc.date.accessioned | 2022-03-09T01:10:48Z | - |
dc.date.available | 2022-03-09T01:10:48Z | - |
dc.date.issued | 2016-12 | - |
dc.identifier.citation | Current Opinion in Lipidology, 27(6), p. 550-556 | en |
dc.identifier.issn | 1473-6535 | en |
dc.identifier.issn | 0957-9672 | en |
dc.identifier.uri | https://hdl.handle.net/1959.11/48017 | - |
dc.description.abstract | <p><b>Purpose of review</b></p> <p>Dysregulated lipoprotein metabolism leads to increased plasma concentrations of atherogenic lipoproteins. We highlight the findings from recent studies of the effect of lipid-regulating therapies on apolipoprotein metabolism in humans employing endogenous labelling with stable isotopically labelled isotopomers.</p> <p><b>Recent findings</b></p> <p>Fish oil supplementation and niacin treatment both reduce fasting and postprandial triglyceride levels by decreasing the hepatic secretion of VLDL-apoB-100 (apoB) and apoB-48-containing chylomicron particles in obese and/or type 2 diabetes. Niacin also lowers plasma LDL-apoB and Lp(a) levels by increasing catabolism of LDL-apoB and decreasing secretion of Lp(a), respectively. In subjects with hypercholesterolaemia, inhibition of cholesteryl ester transfer protein raises apoA-I and lowers apoB by decreasing and increasing the catabolism of HDL-apoA-I and LDL-apoB, respectively. Antisense oligonucleotides directed at apoB mRNA lowers plasma LDL-cholesterol and apoB chiefly by increasing the catabolism and decreasing the secretion of LDL-apoB in healthy subjects. That apoB ASO treatment does not lower hepatic secretion in humans is unexpected and merits further investigation.</p> <p><b>Summary</b></p> <p>Kinetic studies provide mechanistic insight into the mode of action of lipid lowering therapies and lipoprotein disorders. Understanding the mode of action of new drugs in vivo is important to establish their effective use in clinical practice.</p> | en |
dc.language | en | en |
dc.publisher | Lippincott Williams & Wilkins | en |
dc.relation.ispartof | Current Opinion in Lipidology | en |
dc.title | Recent explanatory trials of the mode of action of drug therapies on lipoprotein metabolism | en |
dc.type | Journal Article | en |
dc.identifier.doi | 10.1097/MOL.0000000000000348 | en |
dc.identifier.pmid | 27749370 | en |
local.contributor.firstname | Dick C | en |
local.contributor.firstname | P Hugh R | en |
local.contributor.firstname | Gerald F | en |
local.profile.school | Faculty of Medicine and Health | en |
local.profile.email | pbarret6@une.edu.au | en |
local.output.category | C1 | en |
local.record.place | au | en |
local.record.institution | University of New England | en |
local.publisher.place | United Kingdom | en |
local.format.startpage | 550 | en |
local.format.endpage | 556 | en |
local.identifier.scopusid | 84991464485 | en |
local.peerreviewed | Yes | en |
local.identifier.volume | 27 | en |
local.identifier.issue | 6 | en |
local.contributor.lastname | Chan | en |
local.contributor.lastname | Barrett | en |
local.contributor.lastname | Watts | en |
dc.identifier.staff | une-id:pbarret6 | en |
local.profile.orcid | 0000-0003-3223-6125 | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.identifier.unepublicationid | une:1959.11/48017 | en |
dc.identifier.academiclevel | Academic | en |
dc.identifier.academiclevel | Academic | en |
dc.identifier.academiclevel | Academic | en |
local.title.maintitle | Recent explanatory trials of the mode of action of drug therapies on lipoprotein metabolism | en |
local.relation.fundingsourcenote | D.C.C. is a Research Fellow of the Royal Perth Hospital (RPH) Medical Research Foundation. P.H.R.B. is an NHMRC Senior Research Fellow. | en |
local.output.categorydescription | C1 Refereed Article in a Scholarly Journal | en |
local.search.author | Chan, Dick C | en |
local.search.author | Barrett, P Hugh R | en |
local.search.author | Watts, Gerald F | en |
local.uneassociation | No | en |
local.atsiresearch | No | en |
local.sensitive.cultural | No | en |
local.identifier.wosid | 000388006300002 | en |
local.year.published | 2016 | en |
local.fileurl.closedpublished | https://rune.une.edu.au/web/retrieve/e4f5b8df-cd18-4a04-8c38-13813eb6cca3 | en |
local.subject.for2020 | 320101 Cardiology (incl. cardiovascular diseases) | en |
local.subject.seo2020 | 200105 Treatment of human diseases and conditions | en |
Appears in Collections: | Journal Article |
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