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https://hdl.handle.net/1959.11/4598
Title: | Psychological impact of genetic testing in women from high-risk breast cancer families | Contributor(s): | Meiser, B (author); Butow, P (author); Friedlander, M (author); Barrett, A (author); Schnieden, V (author); Watson, M (author); Brown, Judith Elizabeth (author); Tucker, K (author) | Publication Date: | 2002 | DOI: | 10.1016/S0959-8049(02)00264-2 | Handle Link: | https://hdl.handle.net/1959.11/4598 | Abstract: | Psychological adjustment in 90 women (30 carriers and 60 non-carriers) who had undergone genetic testing for mutations in BRCA1 and BRCA2 breast/ovarian cancer susceptibility genes was compared with that of 53 women who were not offered genetic testing. Women were assessed prior to genetic testing and 7–10 days, 4 and 12 months after carrier status disclosure using self-administered questionnaires. Compared with women not offered testing, mutation carriers had significantly higher breast cancer distress 7–10 days (t=2.80, P=0.005) and 12 months (t=2.01, P=0.045) post-notification. Non-carriers showed a significant decrease in state anxiety 7–10 days post-notification (t=2.27, P=0.024) and in depression 4 months post-notification (t=2.26, P=0.024), compared with women not offered testing. These data show that non-carriers derive psychological benefits from genetic testing. Women testing positive may anticipate a sustained increase in breast cancer distress following disclosure, although no other adverse psychological outcomes were observed in this group. | Publication Type: | Journal Article | Source of Publication: | European Journal of Cancer, v.38, p. 2025-2031 | Publisher: | Pergamon Press | Place of Publication: | United Kingdom | ISSN: | 1879-0852 0959-8049 1359-6349 |
Fields of Research (FoR) 2008: | 160899 Sociology not elsewhere classified | Socio-Economic Objective (SEO) 2008: | 970116 Expanding Knowledge through Studies of Human Society | Peer Reviewed: | Yes | HERDC Category Description: | C1 Refereed Article in a Scholarly Journal | Publisher/associated links: | http://trove.nla.gov.au/work/5841937?selectedversion=NBD7341457 |
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Appears in Collections: | Journal Article |
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