Please use this identifier to cite or link to this item: https://hdl.handle.net/1959.11/3968
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dc.contributor.authorKennett, Eleanor Cen
dc.contributor.authorOgawa, Erien
dc.contributor.authorAgar, Nihal Sen
dc.contributor.authorGodwin, Ian Roberten
dc.contributor.authorBubb, William Aen
dc.contributor.authorKuchel, Philip Wen
dc.date.accessioned2009-12-21T16:27:00Z
dc.date.issued2005en
dc.identifier.citationThe International Journal of Biochemistry and Cell Biology, 37(7), p. 1438-1445en
dc.identifier.issn1878-5875en
dc.identifier.issn1357-2725en
dc.identifier.urihttps://hdl.handle.net/1959.11/3968en
dc.description.abstractThe effect of extracellular NADH on the rate of reduction of nitrite-induced methaemoglobin in erythrocytes from man, cattle, dog, horse, grey kangaroo, pig and sheep was investigated. Extracellular NADH was found to enhance the rate of methaemoglobin reduction in man, dog, pig and kangaroo erythrocytes, but had essentially no effect on the rate of methaemoglobin reduction in erythrocytes from cattle, horse and sheep. In erythrocytes of those animals affected by extracellular NADH the rate of reduction of metHb in the presence of NADH was the same or greater than that observed in the presence of nutrients such as glucose and inosine. The combination of nutrient and NADH produced a more profound increase in the rate of methaemoglobin reduction. The rate of methaemoglobin reduction in all cases was significantly less than that observed with methylene blue, the standard treatment of methaemoglobinaemia. Extracellular NADH was found to indirectly increase the intracellular NADH concentration through displacement of the pseudo-equilibrium of the intracellular LDH reaction and relied upon the presence of sufficient LDH activity released into the extracellular medium through haemolysis. The lack of response of cattle, horse and sheep RBCs to extracellular NADH was found to derive mainly from their low extracellular LDH activity, but also correlated with their lower NADH-methaemoglobin reductase activity compared to the other species. © 2005 Elsevier Ltd. All rights reserved.en
dc.languageenen
dc.publisherElsevieren
dc.relation.ispartofThe International Journal of Biochemistry and Cell Biologyen
dc.titleInvestigation of methaemoglobin reduction by extracellular NADH in mammalian erythrocytesen
dc.typeJournal Articleen
dc.identifier.doi10.1016/j.biocel.2005.02.001en
dc.subject.keywordsAnimal Nutritionen
local.contributor.firstnameEleanor Cen
local.contributor.firstnameErien
local.contributor.firstnameNihal Sen
local.contributor.firstnameIan Roberten
local.contributor.firstnameWilliam Aen
local.contributor.firstnamePhilip Wen
local.subject.for2008070204 Animal Nutritionen
local.subject.seo2008830311 Sheep - Woolen
local.profile.schoolSchool of Environmental and Rural Scienceen
local.profile.emailigodwin@une.edu.auen
local.output.categoryC1en
local.record.placeauen
local.record.institutionUniversity of New Englanden
local.identifier.epublicationsrecordpes:4223en
local.publisher.placeUnited Kingdomen
local.format.startpage1438en
local.format.endpage1445en
local.peerreviewedYesen
local.identifier.volume37en
local.identifier.issue7en
local.contributor.lastnameKennetten
local.contributor.lastnameOgawaen
local.contributor.lastnameAgaren
local.contributor.lastnameGodwinen
local.contributor.lastnameBubben
local.contributor.lastnameKuchelen
dc.identifier.staffune-id:igodwinen
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.identifier.unepublicationidune:4065en
dc.identifier.academiclevelAcademicen
local.title.maintitleInvestigation of methaemoglobin reduction by extracellular NADH in mammalian erythrocytesen
local.output.categorydescriptionC1 Refereed Article in a Scholarly Journalen
local.description.statisticsepubsVisitors: 810<br />Views: 837<br />Downloads: 0en
local.search.authorKennett, Eleanor Cen
local.search.authorOgawa, Erien
local.search.authorAgar, Nihal Sen
local.search.authorGodwin, Ian Roberten
local.search.authorBubb, William Aen
local.search.authorKuchel, Philip Wen
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