Please use this identifier to cite or link to this item: https://hdl.handle.net/1959.11/3744
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dc.contributor.authorGordge, Len
dc.contributor.authorRoberts, Juliet Rosemaryen
dc.date.accessioned2009-12-09T16:37:00Z-
dc.date.issued2008-
dc.identifier.citationComparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology, 150(2), p. 90-101en
dc.identifier.issn1531-4332en
dc.identifier.issn1095-6433en
dc.identifier.urihttps://hdl.handle.net/1959.11/3744-
dc.description.abstract'Notomys alexis' (Spinifex hopping mouse) is found in the arid zone of Australia. The structure and function of the kidneys allow this species to conserve water. This study investigated the rate at which 'N. alexis' can reduce urine volume and increase the concentration of electrolytes and solutes when water deprived. It also looked at the response to rehydration, following a period of water deprivation. The laboratory mouse, Mus musculus domesticus, was used for comparison. 'N. alexis' is able to reduce urine volume and increase urine concentration more rapidly than M. m. domesticus when water deprived. This appears to occur prior to any measurable changes in plasma electrolyte concentrations and is not due to reductions in glomerular filtration rate. Gradual water deprivation over a period of 10 days allowed 'N. alexis' to adjust so that urine composition was similar in many ways to animals that had ad libitum access to water, whereas M. m. domesticus required significant water supplementation to maintain body weight at 85% of initial body weight. Ability to concentrate urine rapidly is characteristic of a well-insulated renal medulla [Bankir, L., DeRouffignac, C., 1985. Urinary concentrating ability: insights from comparative anatomy. Am. J. Physiol. 249, R643–666]. However, a well-insulated medulla is normally associated with slow dilution of urine when animals are rehydrated. 'N. alexis' was able to produce dilute urine very rapidly following rehydration of water deprived animals. Physiological control of renal function appears to be complex. Although M. m. domesticus is able to produce concentrated urine, it is unable to survive without free water and responds more slowly to water deprivation.en
dc.languageenen
dc.publisherElsevier Incen
dc.relation.ispartofComparative Biochemistry and Physiology Part A: Molecular & Integrative Physiologyen
dc.titleKidney function in the Spinifex hopping mouse, 'Notomys alexis'en
dc.typeJournal Articleen
dc.identifier.doi10.1016/j.cbpa.2007.02.013en
dc.subject.keywordsAnimal Physiology - Systemsen
local.contributor.firstnameLen
local.contributor.firstnameJuliet Rosemaryen
local.subject.for2008060603 Animal Physiology - Systemsen
local.subject.seo2008970106 Expanding Knowledge in the Biological Sciencesen
local.profile.schoolSchool of Environmental and Rural Scienceen
local.profile.emailjrobert2@une.edu.auen
local.output.categoryC1en
local.record.placeauen
local.record.institutionUniversity of New Englanden
local.identifier.epublicationsrecordpes:6525en
local.publisher.placeUnited States of Americaen
local.format.startpage90en
local.format.endpage101en
local.identifier.scopusid44849109602en
local.peerreviewedYesen
local.identifier.volume150en
local.identifier.issue2en
local.contributor.lastnameGordgeen
local.contributor.lastnameRobertsen
dc.identifier.staffune-id:jrobert2en
local.profile.roleauthoren
local.profile.roleauthoren
local.identifier.unepublicationidune:3838en
dc.identifier.academiclevelAcademicen
local.title.maintitleKidney function in the Spinifex hopping mouse, 'Notomys alexis'en
local.output.categorydescriptionC1 Refereed Article in a Scholarly Journalen
local.search.authorGordge, Len
local.search.authorRoberts, Juliet Rosemaryen
local.uneassociationUnknownen
local.identifier.wosid000257572600002en
local.year.published2008en
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