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https://hdl.handle.net/1959.11/3398
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DC Field | Value | Language |
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dc.contributor.author | Herrid, Muren | en |
dc.contributor.author | O'Shea, Timothy | en |
dc.contributor.author | McFarlane, James R | en |
dc.date.accessioned | 2009-11-26T16:33:00Z | - |
dc.date.issued | 2008 | - |
dc.identifier.citation | Molecular Reproduction and Development, 75(5), p. 874-880 | en |
dc.identifier.issn | 1098-2795 | en |
dc.identifier.issn | 1040-452X | en |
dc.identifier.uri | https://hdl.handle.net/1959.11/3398 | - |
dc.description.abstract | The mechanism by which leptin regulate male reproductive development during postnatal periods remain to be determined. Using immunohistochemistry and reverse transcription-polymerase chain reaction (RT-PCR), we established that leptin is expressed in mouse testis with a cell-type and stage-dependent manner during the postnatal period. In testes of 5-day-old mice, leptin expression was mainly restricted to gonocytes, whereas the immunostaining of leptin was confined to spermatogonia in 10-day-old testes. From Day 20 and onwards, stage-specific expression of leptin was evident in spermatocytes at stages VII-XII of the cycle in the seminiferous epithelium. RT-PCR showed that leptin and its receptor isoforms, Ob-Ra, Ob-Rb, and Ob-Re were all expressed in testes from 5- to 60-day-old mice. The mRNA for Ob-Ra and Ob-Re, but not Ob-Rb or leptin were identified in both immature (14-day-old) and adult (60-day-old) isolated Leydig cells. These results suggest that besides its primary actions at the hypothalamic-pituitary level, leptin has direct effects in the proliferation, differentiation of germ cells and the modulation of testicular steroidogenesis, using both autocrine and paracrine mechanisms. | en |
dc.language | en | en |
dc.publisher | John Wiley & Sons, Inc | en |
dc.relation.ispartof | Molecular Reproduction and Development | en |
dc.title | Ontogeny of Leptin and its Receptor Expression in Mouse Testis During the Postnatal Period | en |
dc.type | Journal Article | en |
dc.identifier.doi | 10.1002/mrd.20796 | en |
dc.subject.keywords | Endocrinology | en |
dc.subject.keywords | Reproduction | en |
local.contributor.firstname | Muren | en |
local.contributor.firstname | Timothy | en |
local.contributor.firstname | James R | en |
local.subject.for2008 | 110306 Endocrinology | en |
local.subject.for2008 | 111404 Reproduction | en |
local.subject.seo2008 | 920114 Reproductive System and Disorders | en |
local.profile.school | School of Environmental and Rural Science | en |
local.profile.school | School of Environmental and Rural Science | en |
local.profile.school | School of Science and Technology | en |
local.profile.email | toshea2@une.edu.au | en |
local.profile.email | jmcfarla@une.edu.au | en |
local.output.category | C1 | en |
local.record.place | au | en |
local.record.institution | University of New England | en |
local.identifier.epublicationsrecord | pes:7082 | en |
local.publisher.place | United States of America | en |
local.format.startpage | 874 | en |
local.format.endpage | 880 | en |
local.identifier.scopusid | 41149134549 | en |
local.peerreviewed | Yes | en |
local.identifier.volume | 75 | en |
local.identifier.issue | 5 | en |
local.contributor.lastname | Herrid | en |
local.contributor.lastname | O'Shea | en |
local.contributor.lastname | McFarlane | en |
dc.identifier.staff | une-id:toshea | en |
dc.identifier.staff | une-id:jmcfarla | en |
local.profile.orcid | 0000-0003-4429-5384 | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.identifier.unepublicationid | une:3485 | en |
dc.identifier.academiclevel | Academic | en |
dc.identifier.academiclevel | Academic | en |
local.title.maintitle | Ontogeny of Leptin and its Receptor Expression in Mouse Testis During the Postnatal Period | en |
local.output.categorydescription | C1 Refereed Article in a Scholarly Journal | en |
local.search.author | Herrid, Muren | en |
local.search.author | O'Shea, Timothy | en |
local.search.author | McFarlane, James R | en |
local.uneassociation | Unknown | en |
local.identifier.wosid | 000254452000020 | en |
local.year.published | 2008 | en |
Appears in Collections: | Journal Article |
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