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Please use this identifier to cite or link to this item: https://hdl.handle.net/1959.11/2922
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dc.contributor.authorChicca, Aen
dc.contributor.authorPellati, Fen
dc.contributor.authorNieri, Pen
dc.contributor.authorAdinolfi, Ben
dc.contributor.authorMatthias, Aen
dc.contributor.authorMassarelli, Ien
dc.contributor.authorBenvenuti, Sen
dc.contributor.authorMartinotti, Een
dc.contributor.authorBianucci, A Men
dc.contributor.authorBone, Kerryen
dc.contributor.authorLehmann, Ren
dc.date.accessioned2009-11-06T15:14:00Z-
dc.date.issued2008-
dc.identifier.citationBritish Journal of Pharmacology, 153(5), p. 879-885en
dc.identifier.issn0007-1188en
dc.identifier.urihttps://hdl.handle.net/1959.11/2922-
dc.description.abstractThe n-hexane extracts of the roots of three medicinally used 'Echinacea' species exhibited cytotoxic activity on human cancer cell lines, with 'Echinacea pallida' found to be the most cytotoxic. Acetylenes are present in 'E. pallida' lipophilic extracts but essentially absent in extracts from the other two species. In the present study, the cytotoxic effects of five compounds, two polyacetylenes (namely, 8-hydroxy-pentadeca-(9E)-ene-11,13-diyn-2-one (1) and pentadeca-(9E)-ene-11,13-diyne-2,8-dione (3)) and three polyenes (namely, 8-hydroxy-pentadeca-(9E,13Z)-dien-11-yn-2-one (2), pentadeca-(9E,13Z)-dien-11-yne-2,8-dione (4) and pentadeca-(8Z,13Z)-dien-11-yn-2-one (5)), isolated from the n-hexane extract of E. pallida roots by bioassay-guided fractionation, were investigated and the potential bioavailability of these compounds in the extract was studied.en
dc.languageenen
dc.publisherJohn Wiley & Sons Ltden
dc.relation.ispartofBritish Journal of Pharmacologyen
dc.titleCytotoxic activity of polyacetylenes and polyenes isolated from roots of 'Echinacea pallida'en
dc.typeJournal Articleen
dc.identifier.doi10.1038/sj.bjp.0707639en
dc.subject.keywordsComplementary and Alternative Medicineen
local.contributor.firstnameAen
local.contributor.firstnameFen
local.contributor.firstnamePen
local.contributor.firstnameBen
local.contributor.firstnameAen
local.contributor.firstnameIen
local.contributor.firstnameSen
local.contributor.firstnameEen
local.contributor.firstnameA Men
local.contributor.firstnameKerryen
local.contributor.firstnameRen
local.subject.for2008110499 Complementary and Alternative Medicine not elsewhere classifieden
local.subject.seo2008860803 Human Pharmaceutical Treatments (e.g. Antibiotics)en
local.profile.schoolSchool of Healthen
local.profile.emailkbone2@une.edu.auen
local.output.categoryC1en
local.record.placeauen
local.record.institutionUniversity of New Englanden
local.identifier.epublicationsrecordpes:6376en
local.publisher.placeUnited Kingdomen
local.format.startpage879en
local.format.endpage885en
local.identifier.scopusid40149084652en
local.peerreviewedYesen
local.identifier.volume153en
local.identifier.issue5en
local.contributor.lastnameChiccaen
local.contributor.lastnamePellatien
local.contributor.lastnameNierien
local.contributor.lastnameAdinolfien
local.contributor.lastnameMatthiasen
local.contributor.lastnameMassarellien
local.contributor.lastnameBenvenutien
local.contributor.lastnameMartinottien
local.contributor.lastnameBianuccien
local.contributor.lastnameBoneen
local.contributor.lastnameLehmannen
dc.identifier.staffune-id:kbone2en
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.identifier.unepublicationidune:3000en
dc.identifier.academiclevelAcademicen
local.title.maintitleCytotoxic activity of polyacetylenes and polyenes isolated from roots of 'Echinacea pallida'en
local.output.categorydescriptionC1 Refereed Article in a Scholarly Journalen
local.search.authorChicca, Aen
local.search.authorPellati, Fen
local.search.authorNieri, Pen
local.search.authorAdinolfi, Ben
local.search.authorMatthias, Aen
local.search.authorMassarelli, Ien
local.search.authorBenvenuti, Sen
local.search.authorMartinotti, Een
local.search.authorBianucci, A Men
local.search.authorBone, Kerryen
local.search.authorLehmann, Ren
local.uneassociationUnknownen
local.identifier.wosid000253588000006en
local.year.published2008en
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