Please use this identifier to cite or link to this item: https://hdl.handle.net/1959.11/2908
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dc.contributor.authorBehnke, JMen
dc.contributor.authorIraqi, Fen
dc.contributor.authorMenge, Den
dc.contributor.authorBaker, RLen
dc.contributor.authorGibson, John Paulen
dc.contributor.authorWakelin, Den
dc.date.accessioned2009-11-06T09:20:00Z
dc.date.issued2003en
dc.identifier.citationJournal of Helminthology, v.77, p. 99-109en
dc.identifier.issn0022-149Xen
dc.identifier.issn1475-2697en
dc.identifier.urihttps://hdl.handle.net/1959.11/2908en
dc.description.abstractThe host-protective immune response to infection with gastrointestinal (GI) nematodes involves a range of interacting processes that begin with recognition of the parasite's antigens and culminate in an inflammatory reaction in the intestinal mucosa. Precisely which immune effectors are responsible for the loss of specific worms is still not known although many candidate effectors have been proposed. However, it is now clear that many different genes regulate the response and that differences between hosts (fast or strong versus slow or weak responses) can be explained by allelic variation in crucial genes associated with the gene cascade that accompanies the immune response and/or genes encoding constitutively expressed receptor/signalling molecules. Major histocompatibility complex (MHC) genes have been recognized for some time as decisive in controlling immunity, and evidence that non-MHC genes are equally, if not more important in this respect has also been available for two decades. Nevertheless, whilst the former have been mapped in mice, only two candidate loci have been proposed for non-MHC genes and relatively little is known about their roles. Now, with the availability of microsatellite markers, it is possible to exploit linkage mapping techniques to identify quantitative trait loci (QTL) responsible for resistance to GI nematodes. Four QTL for resistance to 'Heligmosomoides polygyrus', and additional QTL affecting faecal egg production by the worms and the accompanying immune responses, have been identified. Fine mapping and eventually the identification of the genes (and their alleles) underlying QTL for resistance/susceptibility will permit informed searches for homologues in domestic animals, and human beings, through comparative genomic maps. This information in turn will facilitate targeted breeding to improve resistance in domestic animals and, in human beings, focused application of treatment and control strategies for GI nematodes.en
dc.languageenen
dc.publisherCambridge University Pressen
dc.relation.ispartofJournal of Helminthologyen
dc.titleChasing the genes that control resistance to gastrointestinal nematodesen
dc.typeJournal Articleen
dc.identifier.doi10.1079/JOH2003174en
dc.subject.keywordsAnimal Breedingen
local.contributor.firstnameJMen
local.contributor.firstnameFen
local.contributor.firstnameDen
local.contributor.firstnameRLen
local.contributor.firstnameJohn Paulen
local.contributor.firstnameDen
local.subject.for2008070201 Animal Breedingen
local.subject.seo2008830399 Livestock Raising not elsewhere classifieden
local.profile.schoolSchool of Environmental and Rural Scienceen
local.profile.emailjgibson5@une.edu.auen
local.output.categoryC1en
local.record.placeauen
local.record.institutionUniversity of New Englanden
local.identifier.epublicationsrecordpes:4293en
local.publisher.placeUnited Kingdomen
local.format.startpage99en
local.format.endpage109en
local.peerreviewedYesen
local.identifier.volume77en
local.contributor.lastnameBehnkeen
local.contributor.lastnameIraqien
local.contributor.lastnameMengeen
local.contributor.lastnameBakeren
local.contributor.lastnameGibsonen
local.contributor.lastnameWakelinen
dc.identifier.staffune-id:jgibson5en
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.identifier.unepublicationidune:2986en
dc.identifier.academiclevelAcademicen
local.title.maintitleChasing the genes that control resistance to gastrointestinal nematodesen
local.output.categorydescriptionC1 Refereed Article in a Scholarly Journalen
local.description.statisticsepubsVisitors: 245<br />Views: 245<br />Downloads: 0en
local.search.authorBehnke, JMen
local.search.authorIraqi, Fen
local.search.authorMenge, Den
local.search.authorBaker, RLen
local.search.authorGibson, John Paulen
local.search.authorWakelin, Den
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