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https://hdl.handle.net/1959.11/28362
Title: | Estrogen Receptor Subtype Ligand Selectivity: Molecular Structural Characteristics | Contributor(s): | Agatonovic-Kustrin, Snezana (author); Turner, Joseph V (author) | Publication Date: | 2009 | Handle Link: | https://hdl.handle.net/1959.11/28362 | Abstract: | The action of estrogens is mediated through the estrogen receptor alpha (ERα) and the more recently discovered estrogen receptor beta (ERβ). These estrogen receptor (ER) subtypes have distinct functions and differential tissue distribution patterns. Tissue- or cell-specific estrogenic activity of receptor ligands have become targets of drug research due to the potential to affect and control physiological and disease states such as breast and endometrial carcinoma, osteoporosis, and menopause. Receptor-ligand activity can be achieved in different ways such as by selective binding or selective modulation. These, in turn, are governed by the intermolecular interactions between estrogen receptors and their ligands. | Publication Type: | Book Chapter | Source of Publication: | Estrogens: Production, Functions and Applications, p. 273-306 | Publisher: | Nova Science Publishers, Inc | Place of Publication: | New York, United States of America | ISBN: | 9781607410867 9781608762200 |
Fields of Research (FoR) 2008: | 030402 Biomolecular Modelling and Design 030799 Theoretical and Computational Chemistry not elsewhere classified 030404 Cheminformatics and Quantitative Structure-Activity Relationships |
Socio-Economic Objective (SEO) 2008: | 860803 Human Pharmaceutical Treatments (e.g. Antibiotics) | HERDC Category Description: | B1 Chapter in a Scholarly Book | WorldCat record: | http://www.worldcat.org/oclc/899541855 | Series Name: | Endocrinology Research and Clinical Developments | Editor: | Editor(s): James R Bartos |
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Appears in Collections: | Book Chapter School of Rural Medicine |
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