Please use this identifier to cite or link to this item: https://hdl.handle.net/1959.11/26785
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dc.contributor.authorKalinowski, Thomasen
local.source.editorEditor(s): Gino J Lim and Eva K Leeen
dc.date.accessioned2019-04-24T06:19:41Z-
dc.date.available2019-04-24T06:19:41Z-
dc.date.issued2008-
dc.identifier.citationOptimization in Medicine and Biology, p. 253-286en
dc.identifier.isbn9780849305696en
dc.identifier.isbn9780429246869en
dc.identifier.isbn0849305691en
dc.identifier.urihttps://hdl.handle.net/1959.11/26785-
dc.description.abstractAn important method in cancer treatment is the use of high energetic radiation. To kill tumor cells, the patient is exposed to radiation that is delivered by a linear accelerator whose beam head can be rotated about the treatment couch. Inevitably, the healthy tissue surrounding the tumor is also exposed to some radiation. So the problem arises to arrange the treatment such that the tumor receives a sufficiently high uniform dose while the damage to the normal tissue is as small as possible. The standard approach to this problem is as follows. First the patient body is discretized into the so-called voxels. The set of voxels is then partitioned into three sets: the clinical target volume, the critical structures, and the remaining tissue. There are certain dose constraints for each of these parts. Basically, the dose in the target volume has to be sufficient to kill the cancerous cells and the dose in the critical structures must not destroy the functionality of the corresponding organs. The determination of a combination of radiation fields is usually done by inverse methods based on certain physical models of how the radiation passes through a body. In the early 1990s, the method of intensity modulated radiation therapy (IMRT) was developed to obtain additional flexibility. Using a multileaf collimator (MLC) it is possible to form homogeneous fields of different shapes. By superimposing some homogeneous fields an intensity modulated field is delivered. An MLC consists of two banks of metal leaves that block the radiation and can be shifted to form irregularly shaped beams.en
dc.languageenen
dc.publisherCRC Pressen
dc.relation.ispartofOptimization in Medicine and Biologyen
dc.relation.ispartofseriesEngineering and Management Innovationen
dc.relation.isversionof1en
dc.titleMultileaf Collimator Shape Matrix Decompositionen
dc.typeBook Chapteren
dc.identifier.doi10.1201/9780849305696en
local.contributor.firstnameThomasen
local.subject.for2008010303 Optimisationen
local.subject.for2008010206 Operations Researchen
local.subject.seo2008970101 Expanding Knowledge in the Mathematical Sciencesen
local.profile.schoolSchool of Science and Technologyen
local.profile.emailtkalinow@une.edu.auen
local.output.categoryB1en
local.record.placeauen
local.record.institutionUniversity of New Englanden
local.publisher.placeBoca Raton, United States of Americaen
local.identifier.totalchapters17en
local.format.startpage253en
local.format.endpage286en
local.peerreviewedYesen
local.contributor.lastnameKalinowskien
dc.identifier.staffune-id:tkalinowen
local.profile.orcid0000-0002-8444-6848en
local.profile.roleauthoren
local.identifier.unepublicationidune:1959.11/26785en
dc.identifier.academiclevelAcademicen
local.title.maintitleMultileaf Collimator Shape Matrix Decompositionen
local.output.categorydescriptionB1 Chapter in a Scholarly Booken
local.search.authorKalinowski, Thomasen
Appears in Collections:Book Chapter
School of Science and Technology
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