Please use this identifier to cite or link to this item:
https://hdl.handle.net/1959.11/26570
Title: | Extended-Release Niacin Alters the Metabolism of Plasma Apolipoprotein (Apo) A-I and ApoB-Containing Lipoproteins | Contributor(s): | Lamon-Fava, Stefania (author); Diffenderfer, Margaret R (author); Barrett, P Hugh R (author)![]() |
Publication Date: | 2008-06-19 | Open Access: | Yes | DOI: | 10.1161/ATVBAHA.108.164541![]() |
Handle Link: | https://hdl.handle.net/1959.11/26570 | Open Access Link: | https://www.doi.org/10.1161/ATVBAHA.108.164541![]() |
Abstract: | Objectives— Extended-release niacin effectively lowers plasma TG levels and raises plasma high-density lipoprotein (HDL) cholesterol levels, but the mechanisms responsible for these effects are unclear. Methods and Results— We examined the effects of extended-release niacin (2 g/d) and extended-release niacin (2 g/d) plus lovastatin (40 mg/d), relative to placebo, on the kinetics of apolipoprotein (apo) A-I and apoA-II in HDL, apoB-100 in TG-rich lipoproteins (TRL), intermediate-density lipoproteins (IDL) and low-density lipoproteins (LDL), and apoB-48 in TRL in 5 men with combined hyperlipidemia. Niacin significantly increased HDL cholesterol and apoA-I concentrations, associated with a significant increase in apoA-I production rate (PR) and no change in fractional catabolic rate (FCR). Plasma TRL apoB-100 levels were significantly lowered by niacin, accompanied by a trend toward an increase in FCR and no change in PR. Niacin treatment significantly increased TRL apoB-48 FCR but had no effect on apoB-48 PR. No effects of niacin on concentrations or kinetic parameters of IDL and LDL apoB-100 and HDL apoA-II were noted. The addition of lovastatin to niacin promoted a lowering in LDL apoB-100 attributable to increased LDL apoB-100 FCR. Conclusion— Niacin treatment was associated with significant increases in HDL apoA-I concentrations and production, as well as enhanced clearance of TRL apoB-100 and apoB-48. | Publication Type: | Journal Article | Grant Details: | NHMRC/58-1950-4-401 | Source of Publication: | Arteriosclerosis, Thrombosis, and Vascular Biology, 28(9), p. 1672-1678 | Publisher: | Lippincott Williams & Wilkins | Place of Publication: | United States of America | ISSN: | 1079-5642 1524-4636 |
Fields of Research (FoR) 2008: | 110399 Clinical Sciences not elsewhere classified | Socio-Economic Objective (SEO) 2008: | 920103 Cardiovascular System and Diseases | Peer Reviewed: | Yes | HERDC Category Description: | C1 Refereed Article in a Scholarly Journal |
---|---|
Appears in Collections: | Journal Article |
Files in This Item:
File | Size | Format |
---|
SCOPUSTM
Citations
144
checked on Aug 10, 2024
Page view(s)
1,200
checked on May 5, 2024
Download(s)
2
checked on May 5, 2024
Items in Research UNE are protected by copyright, with all rights reserved, unless otherwise indicated.