Please use this identifier to cite or link to this item: https://hdl.handle.net/1959.11/21172
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dc.contributor.authorWinter, Galen
dc.contributor.authorHazan, Reuten
dc.contributor.authorBakalinsky, Alan Ten
dc.contributor.authorAbeliovich, Hagaien
dc.date.accessioned2017-05-31T14:46:00Z
dc.date.issued2008en
dc.identifier.citationAutophagy, 4(1), p. 28-36en
dc.identifier.issn1554-8635en
dc.identifier.issn1554-8627en
dc.identifier.urihttps://hdl.handle.net/1959.11/21172en
dc.description.abstractWeak organic acids are an important class of food preservatives that are particularly efficacious towards yeast and fungal spoilage. While acids with small aliphatic chains appear to function by acidification of the cytosol and are required at high concentrations to inhibit growth, more hydrophobic organic acids such as sorbic and benzoic acid have been suggested to function by perturbing membrane dynamics and are growth-inhibitory at much lower concentrations. We previously demonstrated that benzoic acid has selective effects on membrane trafficking in 'Saccharomyces cerevisiae'. Benzoic acid selectively blocks macroautophagy in 'S. cerevisiae' while acetic acid does not, and sorbic acid does so to a lesser extent. Indeed, while both benzoic acid and nitrogen starvation are cytostatic when assayed separately, the combination of these treatments is cytocidal, because macroautophagy is essential for survival during nitrogen starvation. In this report, we demonstrate that 'Zygosaccharomyces bailii', a food spoilage yeast with relatively high resistance to weak acid stress, also exhibits a cytocidal response to the combination of benzoic acid and nitrogen starvation. In addition, we show that nitrogen starvation can be replaced by caffeine supplementation. Caffeine induces a starvation response that includes the induction of macroautophagy, and the combination of caffeine and benzoic acid is cytocidal, as predicted from the nitrogen starvation data.en
dc.languageenen
dc.publisherTaylor & Francisen
dc.relation.ispartofAutophagyen
dc.titleCaffeine induces macroautophagy and confers a cytocidal effect on food spoilage yeast in combination with benzoic aciden
dc.typeJournal Articleen
dc.identifier.doi10.4161/auto.5127en
dc.subject.keywordsCell Metabolismen
local.contributor.firstnameGalen
local.contributor.firstnameReuten
local.contributor.firstnameAlan Ten
local.contributor.firstnameHagaien
local.subject.for2008060104 Cell Metabolismen
local.subject.seo2008970106 Expanding Knowledge in the Biological Sciencesen
local.profile.schoolSchool of Science and Technologyen
local.profile.emailgwinterz@une.edu.auen
local.output.categoryC1en
local.record.placeauen
local.record.institutionUniversity of New Englanden
local.identifier.epublicationsrecordune-20170327-121713en
local.publisher.placeUnited States of Americaen
local.format.startpage28en
local.format.endpage36en
local.peerreviewedYesen
local.identifier.volume4en
local.identifier.issue1en
local.contributor.lastnameWinteren
local.contributor.lastnameHazanen
local.contributor.lastnameBakalinskyen
local.contributor.lastnameAbeliovichen
dc.identifier.staffune-id:gwinterzen
local.profile.orcid0000-0003-3789-395Xen
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.identifier.unepublicationidune:21364en
local.identifier.handlehttps://hdl.handle.net/1959.11/21172en
dc.identifier.academiclevelAcademicen
local.title.maintitleCaffeine induces macroautophagy and confers a cytocidal effect on food spoilage yeast in combination with benzoic aciden
local.output.categorydescriptionC1 Refereed Article in a Scholarly Journalen
local.description.statisticsepubsVisitors: 13<br />Views: 13<br />Downloads: 0en
local.search.authorWinter, Galen
local.search.authorHazan, Reuten
local.search.authorBakalinsky, Alan Ten
local.search.authorAbeliovich, Hagaien
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