Please use this identifier to cite or link to this item: https://hdl.handle.net/1959.11/20556
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dc.contributor.authorCoumans, Joëlle V Fen
dc.contributor.authorPalanisamy, Suresh K Aen
dc.contributor.authorMcFarlane, Jimen
dc.contributor.authorMoens, Pierre D Jen
dc.date.accessioned2017-04-26T17:15:00Z-
dc.date.issued2016-
dc.identifier.citationInternational Journal of Molecular Sciences, 17(4), p. 1-19en
dc.identifier.issn1422-0067en
dc.identifier.urihttps://hdl.handle.net/1959.11/20556-
dc.description.abstractMental health disorders have become worldwide health priorities. It is estimated that in the next 20 years they will account for a 16 trillion United State dollars (US$) loss. Up to now, the underlying pathophysiology of psychiatric disorders remains elusive. Altered cytoskeleton proteins expression that may influence the assembly, organization and maintenance of cytoskeletal integrity has been reported in major depressive disorders, schizophrenia and to some extent bipolar disorders. The use of quantitative proteomics, dynamic microscopy and super-resolution microscopy to investigate disease-specific protein signatures holds great promise to improve our understanding of these disorders. In this review, we present the currently available quantitative proteomic approaches use in neurology, gel-based, stable isotope-labelling and label-free methodologies and evaluate their strengths and limitations. We also reported on enrichment/subfractionation methods that target the cytoskeleton associated proteins and discuss the need of alternative methods for further characterization of the neurocytoskeletal proteome. Finally, we present live cell imaging approaches and emerging dynamic microscopy technology that will provide the tools necessary to investigate protein interactions and their dynamics in the whole cells. While these areas of research are still in their infancy, they offer huge potential towards the understanding of the neuronal network stability and its modification across neuropsychiatric disorders.en
dc.languageenen
dc.publisherMDPI AGen
dc.relation.ispartofInternational Journal of Molecular Sciencesen
dc.titleProteomic and Microscopic Strategies towards the Analysis of the Cytoskeletal Networks in Major Neuropsychiatric Disordersen
dc.typeJournal Articleen
dc.identifier.doi10.3390/ijms17040581en
dcterms.accessRightsGolden
dc.subject.keywordsCentral Nervous Systemen
dc.subject.keywordsPsychiatry (incl. Psychotherapy)en
dc.subject.keywordsMedical Biochemistry: Proteins and Peptides (incl. Medical Proteomics)en
local.contributor.firstnameJoëlle V Fen
local.contributor.firstnameSuresh K Aen
local.contributor.firstnameJimen
local.contributor.firstnamePierre D Jen
local.subject.for2008110106 Medical Biochemistry: Proteins and Peptides (incl. Medical Proteomics)en
local.subject.for2008110903 Central Nervous Systemen
local.subject.for2008110319 Psychiatry (incl. Psychotherapy)en
local.subject.seo2008920410 Mental Healthen
local.subject.seo2008920112 Neurodegenerative Disorders Related to Ageingen
local.subject.seo2008920111 Nervous System and Disordersen
local.profile.schoolSchool of Rural Medicineen
local.profile.schoolSchool of Science and Technologyen
local.profile.schoolSchool of Science and Technologyen
local.profile.emailjmoensco@une.edu.auen
local.profile.emailjmcfarla@une.edu.auen
local.profile.emailpmoens@une.edu.auen
local.output.categoryC1en
local.record.placeauen
local.record.institutionUniversity of New Englanden
local.identifier.epublicationsrecordune-chute-20170321-095852en
local.publisher.placeSwitzerlanden
local.format.startpage1en
local.format.endpage19en
local.identifier.scopusid84964296180en
local.peerreviewedYesen
local.identifier.volume17en
local.identifier.issue4en
local.access.fulltextYesen
local.contributor.lastnameCoumansen
local.contributor.lastnamePalanisamyen
local.contributor.lastnameMcFarlaneen
local.contributor.lastnameMoensen
dc.identifier.staffune-id:jmoenscoen
dc.identifier.staffune-id:jmcfarlaen
dc.identifier.staffune-id:pmoensen
local.profile.orcid0000-0001-6642-5202en
local.profile.orcid0000-0003-4429-5384en
local.profile.orcid0000-0003-3121-5306en
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.identifier.unepublicationidune:20752en
dc.identifier.academiclevelAcademicen
dc.identifier.academiclevelAcademicen
dc.identifier.academiclevelAcademicen
local.title.maintitleProteomic and Microscopic Strategies towards the Analysis of the Cytoskeletal Networks in Major Neuropsychiatric Disordersen
local.output.categorydescriptionC1 Refereed Article in a Scholarly Journalen
local.search.authorCoumans, Joëlle V Fen
local.search.authorPalanisamy, Suresh K Aen
local.search.authorMcFarlane, Jimen
local.search.authorMoens, Pierre D Jen
local.uneassociationUnknownen
local.identifier.wosid000374585300160en
local.year.published2016en
local.fileurl.closedpublishedhttps://rune.une.edu.au/web/retrieve/f27197cd-6a88-457c-bcdf-8cb93e1e3272en
local.subject.for2020320506 Medical biochemistry - proteins and peptides (incl. medical proteomics)en
local.subject.for2020320903 Central nervous systemen
local.subject.for2020320221 Psychiatry (incl. psychotherapy)en
local.subject.seo2020200409 Mental healthen
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