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Please use this identifier to cite or link to this item: https://hdl.handle.net/1959.11/20514
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dc.contributor.authorSuthagar, Kajithaen
dc.contributor.authorWatson, Andrew J Aen
dc.contributor.authorWilkinson, Brendanen
dc.contributor.authorFairbanks, Antony Jen
dc.date.accessioned2017-04-21T16:45:00Z-
dc.date.issued2015-
dc.identifier.citationEuropean Journal of Medicinal Chemistry, v.102, p. 153-166en
dc.identifier.issn1768-3254en
dc.identifier.issn0223-5234en
dc.identifier.urihttps://hdl.handle.net/1959.11/20514-
dc.description.abstractA series of arabinose glycosyl sulfamides with varying alkyl chain types and lengths were synthesised as mimics of decaprenolphosphoarabinose (DPA), and as potential inhibitors of mycobacterial cell wall biosynthesis. Unprecedented conversion of the desired furanose to the thermodynamically more stable pyranose form occurred during final de-protection. Biological testing against 'Mycobacterium smegmatis' revealed low to moderate anti-mycobacterial activity with marked dependence on alkyl chain length, which in the case of mono-substituted sulfamides was maximal for a C-10 chain.en
dc.languageenen
dc.publisherElsevier Massonen
dc.relation.ispartofEuropean Journal of Medicinal Chemistryen
dc.titleSynthesis of arabinose glycosyl sulfamides as potential inhibitors of mycobacterial cell wall biosynthesisen
dc.typeJournal Articleen
dc.identifier.doi10.1016/j.ejmech.2015.07.050en
dc.subject.keywordsMolecular Medicineen
dc.subject.keywordsBiologically Active Moleculesen
dc.subject.keywordsOrganic Chemical Synthesisen
local.contributor.firstnameKajithaen
local.contributor.firstnameAndrew J Aen
local.contributor.firstnameBrendanen
local.contributor.firstnameAntony Jen
local.subject.for2008030401 Biologically Active Moleculesen
local.subject.for2008030405 Molecular Medicineen
local.subject.for2008030503 Organic Chemical Synthesisen
local.subject.seo2008970106 Expanding Knowledge in the Biological Sciencesen
local.subject.seo2008970103 Expanding Knowledge in the Chemical Sciencesen
local.subject.seo2008929999 Health not elsewhere classifieden
local.profile.schoolSchool of Science and Technologyen
local.profile.emailbwilkin7@une.edu.auen
local.output.categoryC1en
local.record.placeauen
local.record.institutionUniversity of New Englanden
local.identifier.epublicationsrecordune-20170323-105356en
local.publisher.placeFranceen
local.format.startpage153en
local.format.endpage166en
local.identifier.scopusid84938911922en
local.peerreviewedYesen
local.identifier.volume102en
local.contributor.lastnameSuthagaren
local.contributor.lastnameWatsonen
local.contributor.lastnameWilkinsonen
local.contributor.lastnameFairbanksen
dc.identifier.staffune-id:bwilkin7en
local.profile.orcid0000-0003-1866-6540en
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.identifier.unepublicationidune:20709en
dc.identifier.academiclevelAcademicen
local.title.maintitleSynthesis of arabinose glycosyl sulfamides as potential inhibitors of mycobacterial cell wall biosynthesisen
local.output.categorydescriptionC1 Refereed Article in a Scholarly Journalen
local.search.authorSuthagar, Kajithaen
local.search.authorWatson, Andrew J Aen
local.search.authorWilkinson, Brendanen
local.search.authorFairbanks, Antony Jen
local.uneassociationUnknownen
local.year.published2015en
local.subject.for2020340406 Molecular medicineen
local.subject.for2020340401 Biologically active moleculesen
local.subject.for2020340503 Organic chemical synthesisen
local.subject.seo2020280102 Expanding knowledge in the biological sciencesen
local.subject.seo2020280105 Expanding knowledge in the chemical sciencesen
local.codeupdate.date2022-02-13T16:34:17.588en
local.codeupdate.epersonbwilkin7@une.edu.auen
local.codeupdate.finalisedtrueen
local.original.for2020340406 Molecular medicineen
local.original.for2020340503 Organic chemical synthesisen
local.original.for2020340401 Biologically active moleculesen
local.original.seo2020280105 Expanding knowledge in the chemical sciencesen
local.original.seo2020undefineden
local.original.seo2020280102 Expanding knowledge in the biological sciencesen
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