Please use this identifier to cite or link to this item: https://hdl.handle.net/1959.11/20298
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dc.contributor.authorArmstrong, Linus T Den
dc.contributor.authorMagnusson, Mark Ren
dc.contributor.authorGuppy, Michelleen
dc.date.accessioned2017-03-29T16:53:00Z-
dc.date.issued2015-
dc.identifier.citationPlastic and Reconstructive Surgery Global Open, 3(12), p. 1-7en
dc.identifier.issn2169-7574en
dc.identifier.urihttps://hdl.handle.net/1959.11/20298-
dc.description.abstractBackground: The facial embryologic fusion planes as regions of mesenchymal and ectodermal fusion of the primordial facial processes during embryological development have been suggested to influence the spread, invasiveness, pathogenesis, and recurrence of cutaneous carcinoma. This study sought to establish whether basal cell carcinoma (BCC) originating in embryologic fusion planes has a greater propensity for earlier depth of invasion, leading to an increased rate of lesion recurrence. Methods: Facial BCCs excised in a single surgeon practice over 2 years were allocated into 2 anatomic domains according to their correlation with embryologic fusion planes. Lesion depth of invasion, surface area, and margins of excision were analyzed in conjunction with recurrence data over the following 70-80 months. Results: Of the 331 lesions examined, 70 were located in embryologic fusion planes. No difference was found in the mean surface area and depth of invasion for lesions located in the 2 domains (P > 0.05). Ten lesion recurrences were identified, none of which were located in embryologic fusion planes. Recurrent lesions were excised with a significantly greater percentage of close and incomplete excision margins (P < 0.05). Conclusions: BCC arising in embryologic fusion planes are not more invasive or at greater risk of recurrence. Excision margins seem to have the greatest influence on lesion recurrence. Because of the paucity of superfluous tissue and the cosmetic and functionally sensitive nature of these areas of embryologic fusion, specialist treatment of these lesions is recommended to ensure that adequacy of excision is not neglected at the cost of ease of closure and cosmesis.en
dc.languageenen
dc.publisherLippincott Williams & Wilkinsen
dc.relation.ispartofPlastic and Reconstructive Surgery Global Openen
dc.titleThe Role of Embryologic Fusion Planes in the Invasiveness and Recurrence of Basal Cell Carcinoma: A Classic Mix-Up of Causation and Correlationen
dc.typeJournal Articleen
dc.identifier.doi10.1097/gox.0000000000000571en
dcterms.accessRightsGolden
dc.subject.keywordsSurgeryen
local.contributor.firstnameLinus T Den
local.contributor.firstnameMark Ren
local.contributor.firstnameMichelleen
local.subject.for2008110323 Surgeryen
local.subject.seo2008920102 Cancer and Related Disordersen
local.profile.schoolSchool of Rural Medicineen
local.profile.emailmguppy2@une.edu.auen
local.output.categoryC1en
local.record.placeauen
local.record.institutionUniversity of New Englanden
local.identifier.epublicationsrecordune-20170307-142240en
local.publisher.placeUnited States of Americaen
local.format.startpage1en
local.format.endpage7en
local.identifier.scopusid85034706350en
local.peerreviewedYesen
local.identifier.volume3en
local.identifier.issue12en
local.title.subtitleA Classic Mix-Up of Causation and Correlationen
local.access.fulltextYesen
local.contributor.lastnameArmstrongen
local.contributor.lastnameMagnussonen
local.contributor.lastnameGuppyen
dc.identifier.staffune-id:mguppy2en
local.profile.orcid0000-0001-7256-4938en
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.identifier.unepublicationidune:20496en
dc.identifier.academiclevelAcademicen
local.title.maintitleThe Role of Embryologic Fusion Planes in the Invasiveness and Recurrence of Basal Cell Carcinomaen
local.output.categorydescriptionC1 Refereed Article in a Scholarly Journalen
local.search.authorArmstrong, Linus T Den
local.search.authorMagnusson, Mark Ren
local.search.authorGuppy, Michelleen
local.uneassociationUnknownen
local.year.published2015en
local.subject.for2020320226 Surgeryen
local.subject.seo2020200101 Diagnosis of human diseases and conditionsen
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