Please use this identifier to cite or link to this item: https://hdl.handle.net/1959.11/20269
Title: Further evidence of HPA-axis dysregulation and its correlation with depression in Autism Spectrum Disorders: Data from girls
Contributor(s): Sharpley, Christopher  (author)orcid ; Bitsika, Vicki  (author); Andronicos, Nicholas  (author)orcid ; Agnew, Linda  (author)orcid 
Publication Date: 2016
DOI: 10.1016/j.physbeh.2016.09.003
Handle Link: https://hdl.handle.net/1959.11/20269
Abstract: To further describe Hypothalamus-Pituitary-Adrenal (HPA) axis activity in children with Autism Spectrum Disorder (ASD), the Diurnal Fluctuation (DF) and Cortisol Awakening Response (CAR)were investigated in a sample of 39 high functioning girls with ASD. Although group mean data conformed to the DF and CAR models, over half of the participants showed inverse CAR and over 14% had inverted DF cortisol concentrations. Examination of three potential sets of predictor factors (physiological, ASD-related, and mood) revealed that only self-reported Major Depressive Disorder was significantly associated with CAR status, and that the girls' concern about dying or suicide was the most powerful contributor to the variance in CAR status. These findings add to the literature regarding the HPA axis dysfunction in children with ASD.
Publication Type: Journal Article
Source of Publication: Physiology & Behavior, v.167, p. 110-117
Publisher: Elsevier Inc
Place of Publication: United States of America
ISSN: 0031-9384
1873-507X
Field of Research (FOR): 110903 Central Nervous System
110319 Psychiatry (incl. Psychotherapy)
Socio-Economic Outcome Codes: 920111 Nervous System and Disorders
Peer Reviewed: Yes
HERDC Category Description: C1 Refereed Article in a Scholarly Journal
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