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https://hdl.handle.net/1959.11/20176
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DC Field | Value | Language |
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dc.contributor.author | Denham, Joshua | en |
dc.contributor.author | Prestes, Priscilla R | en |
dc.date.accessioned | 2017-03-13T18:28:00Z | - |
dc.date.issued | 2016 | - |
dc.identifier.citation | Frontiers in Genetics, v.7, p. 1-8 | en |
dc.identifier.issn | 1664-8021 | en |
dc.identifier.uri | https://hdl.handle.net/1959.11/20176 | - |
dc.description.abstract | MicroRNAs (miRNAs) are small non-coding RNA molecules that regulate gene expression post-transcriptionally. Evidence indicating miRNAs influence exercise-induced health and performance adaptations is mounting. Circulating miRNAs are responsible for intercellular communication and could serve as biomarkers for disease and exercise-related traits. Such biomarkers would contribute to exercise screening, monitoring, and the development of personalized exercise prescription. Accordingly, we investigated the impact of long-term strenuous aerobic exercise training and a single bout of maximal aerobic exercise on five muscle-enriched miRNAs implicated in exercise adaptations (miR-1, miR-133a, miR-181a, miR-486, and miR-494). We also determined linear correlations between miRNAs, resting heart rate, and maximum oxygen uptake (VO₂max). We used TaqMan assay quantitative polymerase chain reaction to analyze the abundance of miR-1, miR-133a, miR-181a, miR-486, and miR-494 in resting whole blood of 67 endurance athletes and 61 healthy controls. Relative to controls, endurance athletes exhibited increased miR-1, miR-486, and miR-494 content (1.26- to 1.58-fold change, all p < 0.05). miR-1, miR-133a, and miR-486 were decreased immediately after maximal aerobic exercise (0.64- to 0.76-fold change, all p < 0.01) performed by 19 healthy, young men (20.7 ± 2.4 years). Finally, we observed positive correlations between miRNA abundance and www.frontiersin.orgO2 max (miR-1 and miR-486) and an inverse correlation between miR-486 and resting heart rate. Therefore, muscle-enriched miRNAs isolated from whole blood are regulated by acute and long-term aerobic exercise training and could serve as biomarkers of cardiorespiratory fitness. | en |
dc.language | en | en |
dc.publisher | Frontiers Research Foundation | en |
dc.relation.ispartof | Frontiers in Genetics | en |
dc.title | Muscle-Enriched MicroRNAs Isolated from Whole Blood Are Regulated by Exercise and Are Potential Biomarkers of Cardiorespiratory Fitness | en |
dc.type | Journal Article | en |
dc.identifier.doi | 10.3389/fgene.2016.00196 | en |
dcterms.accessRights | Gold | en |
dc.subject.keywords | Epigenetics (incl. Genome Methylation and Epigenomics) | en |
dc.subject.keywords | Exercise Physiology | en |
dc.subject.keywords | Gene Expression (incl. Microarray and other genome-wide approaches) | en |
local.contributor.firstname | Joshua | en |
local.contributor.firstname | Priscilla R | en |
local.subject.for2008 | 110602 Exercise Physiology | en |
local.subject.for2008 | 060404 Epigenetics (incl. Genome Methylation and Epigenomics) | en |
local.subject.for2008 | 060405 Gene Expression (incl. Microarray and other genome-wide approaches) | en |
local.subject.seo2008 | 970106 Expanding Knowledge in the Biological Sciences | en |
local.subject.seo2008 | 970111 Expanding Knowledge in the Medical and Health Sciences | en |
local.profile.school | School of Science and Technology | en |
local.profile.email | jdenham2@une.edu.au | en |
local.output.category | C1 | en |
local.record.place | au | en |
local.record.institution | University of New England | en |
local.identifier.epublicationsrecord | une-20170105-150854 | en |
local.publisher.place | Switzerland | en |
local.identifier.runningnumber | Article 196 | en |
local.format.startpage | 1 | en |
local.format.endpage | 8 | en |
local.peerreviewed | Yes | en |
local.identifier.volume | 7 | en |
local.access.fulltext | Yes | en |
local.contributor.lastname | Denham | en |
local.contributor.lastname | Prestes | en |
dc.identifier.staff | une-id:jdenham2 | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.identifier.unepublicationid | une:20374 | en |
dc.identifier.academiclevel | Academic | en |
local.title.maintitle | Muscle-Enriched MicroRNAs Isolated from Whole Blood Are Regulated by Exercise and Are Potential Biomarkers of Cardiorespiratory Fitness | en |
local.output.categorydescription | C1 Refereed Article in a Scholarly Journal | en |
local.search.author | Denham, Joshua | en |
local.search.author | Prestes, Priscilla R | en |
local.uneassociation | Unknown | en |
local.identifier.wosid | 000402675600001 | en |
local.year.published | 2016 | en |
local.fileurl.closedpublished | https://rune.une.edu.au/web/retrieve/600e4658-2835-4dd6-a999-ee6560cb8622 | en |
local.subject.for2020 | 420702 Exercise physiology | en |
local.subject.for2020 | 310504 Epigenetics (incl. genome methylation and epigenomics) | en |
local.subject.for2020 | 310505 Gene expression (incl. microarray and other genome-wide approaches) | en |
local.subject.seo2020 | 280102 Expanding knowledge in the biological sciences | en |
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