Please use this identifier to cite or link to this item: https://hdl.handle.net/1959.11/19684
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dc.contributor.authorBarns, Mitchellen
dc.contributor.authorGondro, Cedricen
dc.contributor.authorTellam, Ross Len
dc.contributor.authorRadley-Crabb, Hannah Gen
dc.contributor.authorGrounds, Miranda Den
dc.contributor.authorShavlakadze, Teaen
dc.date.accessioned2016-12-07T11:31:00Z-
dc.date.issued2014-
dc.identifier.citationThe International Journal of Biochemistry & Cell Biology, v.53, p. 174-185en
dc.identifier.issn1878-5875en
dc.identifier.issn1357-2725en
dc.identifier.urihttps://hdl.handle.net/1959.11/19684-
dc.description.abstractMolecular mechanisms that are associated with age-related denervation and loss of skeletal muscle mass and function (sarcopenia) are described for female C57Bl/6J mice aged 3, 15, 24, 27 and 29 months (m). Changes in mRNAs and proteins associated with myofibre denervation and protein metabolism in ageing muscles are reported, across the transition from healthy adult myofibres to sarcopenia that occurs between 15 and 24 m. This onset of sarcopenia at 24 m, corresponded with increased expression of genes associated with neuromuscular junction denervation including Chnrg, Chrnd, Ncam1, Runx1, Gadd45a and Myog. Sarcopenia in quadriceps muscles also coincided with increased protein levels for Igf1 receptor, Akt and ribosomal protein S6 (Rps6) with increased phosphorylation of Rps6 (Ser235/236) and elevated Murf1 mRNA and protein, but not Fbxo32: many of these changes are also linked to denervation. Global transcription profiling via microarray analysis confirmed these functional themes and highlighted additional themes that may be a consequence of pathology associated with sarcopenia, including changes in fatty acid metabolism, extracellular matrix structure and protein catabolism. Ageing was also associated with increased global gene expression variance, consistent with decreased control of gene regulation.en
dc.languageenen
dc.publisherElsevier Ltden
dc.relation.ispartofThe International Journal of Biochemistry & Cell Biologyen
dc.titleMolecular analyses provide insight into mechanisms underlying sarcopenia and myofibre denervation in old skeletal muscles of miceen
dc.typeJournal Articleen
dc.identifier.doi10.1016/j.biocel.2014.04.025en
dc.subject.keywordsGene Expression (incl. Microarray and other genome-wide approaches)en
local.contributor.firstnameMitchellen
local.contributor.firstnameCedricen
local.contributor.firstnameRoss Len
local.contributor.firstnameHannah Gen
local.contributor.firstnameMiranda Den
local.contributor.firstnameTeaen
local.subject.for2008060405 Gene Expression (incl. Microarray and other genome-wide approaches)en
local.subject.seo2008920116 Skeletal System and Disorders (incl. Arthritis)en
local.profile.schoolSchool of Environmental and Rural Scienceen
local.profile.emailcgondro2@une.edu.auen
local.output.categoryC1en
local.record.placeauen
local.record.institutionUniversity of New Englanden
local.identifier.epublicationsrecordune-chute-20161112-151550en
local.publisher.placeUnited Kingdomen
local.format.startpage174en
local.format.endpage185en
local.peerreviewedYesen
local.identifier.volume53en
local.contributor.lastnameBarnsen
local.contributor.lastnameGondroen
local.contributor.lastnameTellamen
local.contributor.lastnameRadley-Crabben
local.contributor.lastnameGroundsen
local.contributor.lastnameShavlakadzeen
dc.identifier.staffune-id:cgondro2en
local.profile.orcid0000-0003-0666-656Xen
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.identifier.unepublicationidune:19874en
dc.identifier.academiclevelAcademicen
local.title.maintitleMolecular analyses provide insight into mechanisms underlying sarcopenia and myofibre denervation in old skeletal muscles of miceen
local.output.categorydescriptionC1 Refereed Article in a Scholarly Journalen
local.relation.grantdescriptionARC/LP120100520en
local.search.authorBarns, Mitchellen
local.search.authorGondro, Cedricen
local.search.authorTellam, Ross Len
local.search.authorRadley-Crabb, Hannah Gen
local.search.authorGrounds, Miranda Den
local.search.authorShavlakadze, Teaen
local.uneassociationUnknownen
local.identifier.wosid000340340400022en
local.year.published2014en
local.subject.for2020310505 Gene expression (incl. microarray and other genome-wide approaches)en
local.subject.seo2020200101 Diagnosis of human diseases and conditionsen
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