The effect of ageing and hypertension on the proton-coupled transporters PEPT1 and PEPT2 in the renal proximal tubule, and PEPT2 in cardiac sarcolemmal membrane

Abstract

The effect of ageing and hypertension on the proton-coupled transporters PEPT1 and PEPT2 located in the apical membrane of the renal proximal tubule, and on PEPT2 in cardiac sarcolemmal membrane Background: A number of studies have shown the critical importance of the integral membrane cotransporters PEPT1 and PEPT2 in physiology, pathophysiology, pharmacology, and nutrition. This significance lies in the dynamic role of these cotransporters in the uptake of more than 8000 different di-and tripeptide combinations and a wide range of peptidomimetic drugs with clinical and pharmacological relevance. This body of work seeks, for the first time, to systematically investigate prospective changes of PEPT1 and PEPT2 cotransporters in the kidneys and hearts with ageing and/or hypertension at the gene, protein expression, localisation and functional levels.