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Please use this identifier to cite or link to this item: https://hdl.handle.net/1959.11/18460
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dc.contributor.authorCharlesworth, Richarden
dc.contributor.authorAndronicos, Nicholasen
dc.contributor.authorAgnew, Lindaen
dc.date.accessioned2016-01-20T16:41:00Z-
dc.date.issued2015-
dc.identifier.citation39th Annual Meeting of the Australian Society for Biophysics Delegate Handbook, p. 98-99en
dc.identifier.urihttps://hdl.handle.net/1959.11/18460-
dc.description.abstractBackground: Coeliac Disease (CD) is an autoimmune enteropathy targeted against the harmless grain protein gliadin and affects around 1 in 300 people worldwide. The condition causes malabsorptive symptomology and the only current form of treatment is a strict. lifelong gluten-free diet. To date, the exact mechanisms of this autoimmune response have yet to be elucidated. Aims: We have developed and tested a fully-annotated and MIQE compliant 87-gene qRT-PCR array which was specifically designed to investigate the hypothesised immune pathways and processes of active CD. Using duodenal biopsy material from 34 patients with active CD, treated CD and healthy controls; this analysis showed a total of 25 genes which were significantly deferentially expressed between the grades of CD, with a total of 5 genes showing highly significant differential expression and significant linear relationships to the different grades of CD. The aim of this research therefore, was to investigate the expression and localisation of these live genes at the protein level: namely Interferon-y (IFNG), Interleukin 17 (IL17A), Interleukin 18 (IL18), B-lymphocyte Antigen CDI9 (CDI9) and Ectonuelcotide Pyrophosphatasc/Phosphodiesterase 3 (CD203c).en
dc.languageenen
dc.publisherUniversity of New Englanden
dc.relation.ispartof39th Annual Meeting of the Australian Society for Biophysics Delegate Handbooken
dc.titleDetection of Novel Biomarkers of Coeliac Disease at the Protein Level using both Fluoro-Immunohistochemistry and Conventional Immunohistochemistryen
dc.typeConference Publicationen
dc.relation.conferenceASB 2015: 39th Annual Meeting of the Australian Society for Biophysicsen
dc.subject.keywordsGastroenterology and Hepatologyen
dc.subject.keywordsAutoimmunityen
local.contributor.firstnameRicharden
local.contributor.firstnameNicholasen
local.contributor.firstnameLindaen
local.subject.for2008110307 Gastroenterology and Hepatologyen
local.subject.for2008110703 Autoimmunityen
local.subject.seo2008920108 Immune System and Allergyen
local.subject.seo2008920105 Digestive System Disordersen
local.profile.schoolSchool of Science and Technologyen
local.profile.schoolSchool of Science and Technologyen
local.profile.emailrcharle2@une.edu.auen
local.profile.emailnandroni@une.edu.auen
local.profile.emaillagnew2@une.edu.auen
local.output.categoryE3en
local.record.placeauen
local.record.institutionUniversity of New Englanden
local.identifier.epublicationsrecordune-20160115-172559en
local.date.conference22nd - 25th November, 2015en
local.conference.placeArmidale, Australiaen
local.publisher.placeArmidale, Australiaen
local.identifier.runningnumberPoster Abstract P02en
local.format.startpage98en
local.format.endpage99en
local.contributor.lastnameCharlesworthen
local.contributor.lastnameAndronicosen
local.contributor.lastnameAgnewen
dc.identifier.staffune-id:rcharle2en
dc.identifier.staffune-id:nandronien
dc.identifier.staffune-id:lagnew2en
local.profile.orcid0000-0001-5881-2296en
local.profile.orcid0000-0002-2803-0995en
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.identifier.unepublicationidune:18664en
dc.identifier.academiclevelAcademicen
dc.identifier.academiclevelAcademicen
dc.identifier.academiclevelAcademicen
local.title.maintitleDetection of Novel Biomarkers of Coeliac Disease at the Protein Level using both Fluoro-Immunohistochemistry and Conventional Immunohistochemistryen
local.output.categorydescriptionE3 Extract of Scholarly Conference Publicationen
local.conference.detailsASB 2015: 39th Annual Meeting of the Australian Society for Biophysics, Armidale, Australia, 22nd - 25th November, 2015en
local.search.authorCharlesworth, Richarden
local.search.authorAndronicos, Nicholasen
local.search.authorAgnew, Lindaen
local.uneassociationUnknownen
local.year.published2015en
local.subject.for2020320209 Gastroenterology and hepatologyen
local.subject.for2020320403 Autoimmunityen
local.subject.seo2020200101 Diagnosis of human diseases and conditionsen
local.date.start2015-11-22-
local.date.end2015-11-25-
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