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https://hdl.handle.net/1959.11/16481
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DC Field | Value | Language |
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dc.contributor.author | Fogarty, Mark C | en |
dc.contributor.author | de Vito, Giuseppe | en |
dc.contributor.author | Hughes, Ciara M | en |
dc.contributor.author | Burke, George | en |
dc.contributor.author | Brown, John C | en |
dc.contributor.author | McEneny, Jane | en |
dc.contributor.author | Brown, David | en |
dc.contributor.author | McClean, Conor | en |
dc.contributor.author | Davison, Gareth W | en |
dc.date.accessioned | 2015-01-15T13:21:00Z | - |
dc.date.issued | 2013 | - |
dc.identifier.citation | Medicine and Science in Sports and Exercise, 45(8), p. 1469-1477 | en |
dc.identifier.issn | 1530-0315 | en |
dc.identifier.issn | 0195-9131 | en |
dc.identifier.uri | https://hdl.handle.net/1959.11/16481 | - |
dc.description.abstract | Although pharmacological antioxidants have previously been investigated for a prophylactic effect against exercise oxidative stress, it is not known if α-lipoic acid supplementation can protect against DNA damage after high-intensity isolated quadriceps exercise. This randomized controlled investigation was designed to test the hypothesis that 14 d of α-lipoic acid supplementation can attenuate exercise-induced oxidative stress. Methods: Twelve (n = 12) apparently healthy male participants (age = 28 ± 10 yr, stature = 177 ± 12 cm and body mass = 81 ± 15 kg) were randomly assigned to receive either a daily supplement of 1000mg of α-lipoic acid (2 x 500-mg tablets) for 14 d (n = 6) or receive no supplement (n = 6) in a double-blinded experimental approach. Blood and muscle biopsy tissue samples were taken at rest and after the completion of 100 isolated and continuous maximal knee extension (minimum force = 200 N, speed of contraction = 60°.s⁻¹). Results: Exercise increased mitochondrial 8-hydroxy-2-deoxyguanosine (8-OHdG) concentration in both groups (P G 0.05 vs rest) with a concomitant decrease in total antioxidant capacity (P G 0.05 vs rest). There was a marked increase in blood total antioxidant capacity after oral α-lipoic acid supplementation (P < 0.05 vs nonsupplemented), whereas DNA damage (Comet assay and 8-OHdG), lipid peroxidation, and hydrogen peroxide increased after exercise in the non-supplemented group only (P < 0.05 vs supplemented). Exercise increased protein oxidation in both groups (P < 0.05 vs rest). Conclusions: These findings suggest that short-term α-lipoic acid supplementation can selectively protect DNA (but not in muscle mitochondria) and lipids against exercise-induced oxidative stress. | en |
dc.language | en | en |
dc.publisher | Lippincott Williams & Wilkins | en |
dc.relation.ispartof | Medicine and Science in Sports and Exercise | en |
dc.title | Effects of α-lipoic Acid on mtDNA Damage after Isolated Muscle Contractions | en |
dc.type | Journal Article | en |
dc.identifier.doi | 10.1249/MSS.0b013e31828bf31e | en |
dc.subject.keywords | Exercise Physiology | en |
dc.subject.keywords | Sports Medicine | en |
local.contributor.firstname | Mark C | en |
local.contributor.firstname | Giuseppe | en |
local.contributor.firstname | Ciara M | en |
local.contributor.firstname | George | en |
local.contributor.firstname | John C | en |
local.contributor.firstname | Jane | en |
local.contributor.firstname | David | en |
local.contributor.firstname | Conor | en |
local.contributor.firstname | Gareth W | en |
local.subject.for2008 | 110604 Sports Medicine | en |
local.subject.for2008 | 110602 Exercise Physiology | en |
local.subject.seo2008 | 970106 Expanding Knowledge in the Biological Sciences | en |
local.subject.seo2008 | 970111 Expanding Knowledge in the Medical and Health Sciences | en |
local.profile.school | School of Science and Technology | en |
local.profile.email | gdevito@une.edu.au | en |
local.output.category | C1 | en |
local.record.place | au | en |
local.record.institution | University of New England | en |
local.identifier.epublicationsrecord | une-20150112-103521 | en |
local.publisher.place | United States of America | en |
local.format.startpage | 1469 | en |
local.format.endpage | 1477 | en |
local.peerreviewed | Yes | en |
local.identifier.volume | 45 | en |
local.identifier.issue | 8 | en |
local.contributor.lastname | Fogarty | en |
local.contributor.lastname | de Vito | en |
local.contributor.lastname | Hughes | en |
local.contributor.lastname | Burke | en |
local.contributor.lastname | Brown | en |
local.contributor.lastname | McEneny | en |
local.contributor.lastname | Brown | en |
local.contributor.lastname | McClean | en |
local.contributor.lastname | Davison | en |
dc.identifier.staff | une-id:gdevito | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.identifier.unepublicationid | une:16717 | en |
local.identifier.handle | https://hdl.handle.net/1959.11/16481 | en |
dc.identifier.academiclevel | Academic | en |
local.title.maintitle | Effects of α-lipoic Acid on mtDNA Damage after Isolated Muscle Contractions | en |
local.output.categorydescription | C1 Refereed Article in a Scholarly Journal | en |
local.search.author | Fogarty, Mark C | en |
local.search.author | de Vito, Giuseppe | en |
local.search.author | Hughes, Ciara M | en |
local.search.author | Burke, George | en |
local.search.author | Brown, John C | en |
local.search.author | McEneny, Jane | en |
local.search.author | Brown, David | en |
local.search.author | McClean, Conor | en |
local.search.author | Davison, Gareth W | en |
local.uneassociation | Unknown | en |
local.year.published | 2013 | en |
local.subject.for2020 | 320225 Sports medicine | en |
local.subject.for2020 | 420702 Exercise physiology | en |
local.subject.seo2020 | 280102 Expanding knowledge in the biological sciences | en |
Appears in Collections: | Journal Article |
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