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https://hdl.handle.net/1959.11/16461
Title: | Chemical modification of multiwalled carbon nanotube with a bifunctional caged ligand for radioactive labelling | Contributor(s): | Ormsby, Ross W (author); McNally, Tony (author); Mitchell, Christina A (author); Musumeci, Anthony (author); Schiller, Tara (author); Halley, Peter (author); Gahan, Lawrence (author); Martin, Darren (author); Smith, Suzanne V (author); Dunne, Nicholas J (author) | Publication Date: | 2014 | DOI: | 10.1016/j.actamat.2013.10.047 | Handle Link: | https://hdl.handle.net/1959.11/16461 | Abstract: | Carboxyl-functionalized multiwalled carbon nanotubes (MWCNTs) have been successfully radiolabelled with cobalt-57 (⁵⁷Co) ('T'¹/² = 270 days) via the attachment of the bifunctional caged ligand MeAMN₃S₃sar. In this study MeAMN₃S₃sar has been synthesized and coupled to MWCNTs to form the conjugate MWCNT–MeAMN₃S₃sar. Synthesis was confirmed with nuclear magnetic resonance. X-ray photoelectron spectroscopy (XPS) confirmed the conjugation. Non-radioactive labelling of this conjugate was completed with Cu(II) ions to confirm the stability of the MeAMN₃S₃sar after coupling with the MWCNTs. The complexation of the Cu(II) was also confirmed with XPS. Transmission electron microscopy was used to demonstrate that the coupling reaction had a negligible effect on the size and shape of the MWCNTs. Radiolabelling of the MWCNT–MeAMN₃S₃sar conjugate and pristine (untreated) MWCNTs (non-specific) with the gamma-emitting radioactive isotope ⁵⁷Co were compared. The radiolabelling efficiency of the MWCNT–MeAMN₃S₃sar conjugate was significantly higher (95% vs. 0.1%) ('P' ≼ 0.001) than for the unconjugated pristine MWCNTs. This will allow for the potential tracking of nanoparticle movement in vitro and in vivo. | Publication Type: | Journal Article | Source of Publication: | Acta Materialia, v.64, p. 54-61 | Publisher: | Pergamon Press | Place of Publication: | United Kingdom | ISSN: | 1873-2453 1359-6454 |
Fields of Research (FoR) 2008: | 030302 Nanochemistry and Supramolecular Chemistry 030301 Chemical Characterisation of Materials 030399 Macromolecular and Materials Chemistry not elsewhere classified |
Fields of Research (FoR) 2020: | 340207 Metal organic frameworks 340301 Inorganic materials (incl. nanomaterials) 340399 Macromolecular and materials chemistry not elsewhere classified |
Socio-Economic Objective (SEO) 2008: | 970109 Expanding Knowledge in Engineering 970103 Expanding Knowledge in the Chemical Sciences |
Socio-Economic Objective (SEO) 2020: | 280110 Expanding knowledge in engineering 280105 Expanding knowledge in the chemical sciences |
Peer Reviewed: | Yes | HERDC Category Description: | C1 Refereed Article in a Scholarly Journal |
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Appears in Collections: | Journal Article |
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