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https://hdl.handle.net/1959.11/15962
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DC Field | Value | Language |
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dc.contributor.author | Chong, Josephine Y T | en |
dc.contributor.author | Mulet, Xavier | en |
dc.contributor.author | Postma, Almar | en |
dc.contributor.author | Keddie, Daniel | en |
dc.contributor.author | Waddington, Lynne J | en |
dc.contributor.author | Boyd, Ben J | en |
dc.contributor.author | Drummond, Calum J | en |
dc.date.accessioned | 2014-10-27T12:41:00Z | - |
dc.date.issued | 2014 | - |
dc.identifier.citation | Soft Matter, 10(35), p. 6666-6676 | en |
dc.identifier.issn | 1744-6848 | en |
dc.identifier.issn | 1744-683X | en |
dc.identifier.uri | https://hdl.handle.net/1959.11/15962 | - |
dc.description.abstract | Copolymers, particularly Pluronics®, are typically used to sterically stabilise colloidal nanostructured particles composed of a lyotropic liquid crystalline bicontinuous cubic phase (cubosomes). There is a need to design and assess new functionalisable stabilisers for these colloidal drug delivery systems. Six amphiphilic brush copolymers, poly(octadecyl acrylate)-block-poly(polyethylene glycol methyl ether acrylate) (P(ODA)-b-P(PEGA-OMe)), synthesised by reversible addition-fragmentation chain transfer (RAFT), were assessed as novel steric stabilisers for cubosomes. It was found that increasing the density of PEG on the nanostructured particle surface by incorporating a PEG brush design (i.e., brush copolymer), provided comparable and/or increased stabilisation effectiveness compared to a linear PEG structure, Pluronic® F127, which is extensively used for steric stabilisation of cubosomes. Assessment was conducted both prior to and following the removal of the dodecyl trithiocarbonate end-group, by free radical-induced reduction. The reduced (P(ODA)-b-P(PEGA-OMe) copolymers were more effective steric stabilisers for phytantriol and monoolein colloidal particle dispersions than their non-reduced analogues. High throughput characterisation methodologies, including an accelerated stability assay (ASA) and synchrotron small angle X-ray scattering (SAXS), were implemented in this study for the rapid assessment of steric stabiliser effectiveness and lyotropic liquid crystalline phase identification. Phytantriol cubosomes stabilised with P(ODA)-b-P(PEGA-OMe) copolymers exhibited a double diamond cubic phase (Q(2)(D)), whilst monoolein cubosomes exhibited a primitive cubic phase (Q(2)(P)), analogous to those formed using Pluronic® F127. | en |
dc.language | en | en |
dc.publisher | RSC Publications | en |
dc.relation.ispartof | Soft Matter | en |
dc.title | Novel RAFT amphiphilic brush copolymer steric stabilisers for cubosomes: poly(octadecyl acrylate)- block-poly(polyethylene glycol methyl ether acrylate) | en |
dc.type | Journal Article | en |
dc.identifier.doi | 10.1039/c4sm01064g | en |
dc.subject.keywords | Synthesis of Materials | en |
dc.subject.keywords | Polymerisation Mechanisms | en |
local.contributor.firstname | Josephine Y T | en |
local.contributor.firstname | Xavier | en |
local.contributor.firstname | Almar | en |
local.contributor.firstname | Daniel | en |
local.contributor.firstname | Lynne J | en |
local.contributor.firstname | Ben J | en |
local.contributor.firstname | Calum J | en |
local.subject.for2008 | 030305 Polymerisation Mechanisms | en |
local.subject.for2008 | 030306 Synthesis of Materials | en |
local.subject.seo2008 | 970103 Expanding Knowledge in the Chemical Sciences | en |
local.profile.school | School of Science and Technology | en |
local.profile.email | dkeddie@une.edu.au | en |
local.output.category | C1 | en |
local.record.place | au | en |
local.record.institution | University of New England | en |
local.identifier.epublicationsrecord | une-20141023-131020 | en |
local.publisher.place | United Kingdom | en |
local.format.startpage | 6666 | en |
local.format.endpage | 6676 | en |
local.peerreviewed | Yes | en |
local.identifier.volume | 10 | en |
local.identifier.issue | 35 | en |
local.title.subtitle | poly(octadecyl acrylate)- block-poly(polyethylene glycol methyl ether acrylate) | en |
local.contributor.lastname | Chong | en |
local.contributor.lastname | Mulet | en |
local.contributor.lastname | Postma | en |
local.contributor.lastname | Keddie | en |
local.contributor.lastname | Waddington | en |
local.contributor.lastname | Boyd | en |
local.contributor.lastname | Drummond | en |
dc.identifier.staff | une-id:dkeddie | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.identifier.unepublicationid | une:16199 | en |
local.identifier.handle | https://hdl.handle.net/1959.11/15962 | en |
dc.identifier.academiclevel | Academic | en |
local.title.maintitle | Novel RAFT amphiphilic brush copolymer steric stabilisers for cubosomes | en |
local.output.categorydescription | C1 Refereed Article in a Scholarly Journal | en |
local.search.author | Chong, Josephine Y T | en |
local.search.author | Mulet, Xavier | en |
local.search.author | Postma, Almar | en |
local.search.author | Keddie, Daniel | en |
local.search.author | Waddington, Lynne J | en |
local.search.author | Boyd, Ben J | en |
local.search.author | Drummond, Calum J | en |
local.uneassociation | Unknown | en |
local.identifier.wosid | 000341025500008 | en |
local.year.published | 2014 | en |
local.subject.for2020 | 340306 Polymerisation mechanisms | en |
local.subject.for2020 | 340207 Metal organic frameworks | en |
local.subject.seo2020 | 280105 Expanding knowledge in the chemical sciences | en |
Appears in Collections: | Journal Article |
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