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https://hdl.handle.net/1959.11/15890
Title: | Factors associated with feelings of loss of masculinity in men with prostate cancer in the RADAR trial | Contributor(s): | Sharpley, Christopher (author)![]() |
Publication Date: | 2014 | DOI: | 10.1002/pon.3448 | Handle Link: | https://hdl.handle.net/1959.11/15890 | Abstract: | Objectives: To identify the factors underlying prostate cancer (PCa) patients' depression-anxiety, sexual problems, urinary dysfunction and androgen deprivation therapy (ADT)-linked breast changes and hot flushes, and test these as predictors of loss of masculinity (LoM) over 36 months following diagnosis. Methods: One thousand seventy patients from the TROG 03.04 (RADAR) trial the EORTC QLQ C-30 and PR 25 questionnaires, and the International Prostate Cancer Symptom Score of the American Urological Association at baseline, 3, 7, 12, 18, 24 and 36 months. Selected items from these scales were factor-analysed to identify a four-component solution for responses at 18 and 36 months, and these components were regressed against a single-item measuring LoM. Results: Depression-anxiety factor was the most powerful predictor of LoM at both time points, followed by sexual problems of ADT side effects (breast changes and hot flushes). Urinary dysfunction was not a consistent predictor of LoM. Depression-anxiety was also the most significant factor distinguishing between those men who reported LoM and those who did not. Conclusions: Although LoM is often reported as arising from ADT, the relative power of depression-anxiety in predicting LoM, both at the selected time points and using a time-lagged analysis, plus the finding that depression-anxiety was the most consistent difference between men who reported LoM and those who did not, argues for the presence of adverse mood states as being the key ingredient in deciding if PCa patients experience loss of their feelings of masculinity. | Publication Type: | Journal Article | Source of Publication: | Psycho-Oncology, 23(5), p. 524-530 | Publisher: | John Wiley & Sons Ltd | Place of Publication: | United Kingdom | ISSN: | 1099-1611 1057-9249 |
Fields of Research (FoR) 2008: | 110319 Psychiatry (incl Psychotherapy) | Fields of Research (FoR) 2020: | 320903 Central nervous system | Socio-Economic Objective (SEO) 2008: | 920111 Nervous System and Disorders | Socio-Economic Objective (SEO) 2020: | 200409 Mental health | Peer Reviewed: | Yes | HERDC Category Description: | C1 Refereed Article in a Scholarly Journal |
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Appears in Collections: | Journal Article |
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