Please use this identifier to cite or link to this item: https://hdl.handle.net/1959.11/15450
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dc.contributor.authorPurushothaman, Dharmaen
dc.contributor.authorBrown, Wendyen
dc.contributor.authorVanselow, Barbaraen
dc.contributor.authorQuinn, Kimen
dc.contributor.authorWu, Shubiaoen
dc.date.accessioned2014-08-11T12:29:00Z
dc.date.issued2014en
dc.identifier.citationGenetics and Molecular Research, 13(3), p. 5322-5332en
dc.identifier.issn1676-5680en
dc.identifier.urihttps://hdl.handle.net/1959.11/15450en
dc.description.abstractLong chain 'n'-3 fatty acids are beneficial to mammals because of their anti-inflammatory role. However, whether flaxseed oil, which is rich in short chain 'n'-3 fatty acids, has such a role, it has not been extensively examined. This study investigated the supplementation of flaxseed oil on the regulation of genes involved in inflammatory responses such as heat shock proteins ('HSP90' and 'HSP70') and interleukin ('IL1β') in the white blood cells of dogs. Five beagles and 5 greyhounds were supplemented with Melrose® flaxseed oil at the rate of 100 mL/kg food for 21 days. The blood was collected at day 0, 15, and 22 following supplementation. The expression of 3 genes was quantified using real-time polymerase chain reaction. Plasma concentrations of fatty acids such as alpha linolenic acid, eicosapentaenoic acid, docosahexaenoic acid, linoleic acid, and arachidonic acid were measured, and their correlations with changes in gene expression were determined. Flaxseed oil supplementation downregulated the expression of 'HSP90' and 'IL1β' in greyhounds but showed no significant effect on these genes in beagles. 'HSP70' remained unchanged in both breeds following the supplementation. Correlations of 'HSP90' and 'IL1β' expression levels with the plasma fatty acid concentrations on day 22 showed a significant negative correlation in greyhounds. Dietary flaxseed oil altered the expression of genes involved in inflammation in white blood cells. Because the expression of the genes may vary in different breeds, it will be useful to consider breed responses to dietary manipulation in canine nutrition management.en
dc.languageenen
dc.publisherFundacao de Pesquisas Cientificas de Ribeirao Pretoen
dc.relation.ispartofGenetics and Molecular Researchen
dc.titleFlaxseed oil supplementation alters the expression of inflammatory-related genes in dogsen
dc.typeJournal Articleen
dc.identifier.doi10.4238/2014.July.24.11en
dcterms.accessRightsGolden
dc.subject.keywordsAnimal Nutritionen
local.contributor.firstnameDharmaen
local.contributor.firstnameWendyen
local.contributor.firstnameBarbaraen
local.contributor.firstnameKimen
local.contributor.firstnameShubiaoen
local.subject.for2008070204 Animal Nutritionen
local.subject.seo2008839901 Animal Welfareen
local.profile.schoolRSA School Establishment Positionsen
local.profile.schoolSchool of Environmental and Rural Scienceen
local.profile.schoolSchool of Environmental and Rural Scienceen
local.profile.schoolEnvironmental and Rural Scienceen
local.profile.schoolSchool of Environmental and Rural Scienceen
local.profile.emaildpurusho@une.edu.auen
local.profile.emailwbrown@une.edu.auen
local.profile.emailbvansel2@une.edu.auen
local.profile.emailswu3@une.edu.auen
local.output.categoryC1en
local.record.placeauen
local.record.institutionUniversity of New Englanden
local.identifier.epublicationsrecordune-20140807-141519en
local.publisher.placeBrazilen
local.format.startpage5322en
local.format.endpage5332en
local.peerreviewedYesen
local.identifier.volume13en
local.identifier.issue3en
local.access.fulltextYesen
local.contributor.lastnamePurushothamanen
local.contributor.lastnameBrownen
local.contributor.lastnameVanselowen
local.contributor.lastnameQuinnen
local.contributor.lastnameWuen
dc.identifier.staffune-id:dpurushoen
dc.identifier.staffune-id:wbrownen
dc.identifier.staffune-id:bvansel2en
dc.identifier.staffune-id:swu3en
local.profile.orcid0000-0002-5309-3381en
local.profile.orcid0000-0002-1790-6015en
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.identifier.unepublicationidune:15667en
local.identifier.handlehttps://hdl.handle.net/1959.11/15450en
dc.identifier.academiclevelAcademicen
dc.identifier.academiclevelAcademicen
dc.identifier.academiclevelAcademicen
dc.identifier.academiclevelAcademicen
local.title.maintitleFlaxseed oil supplementation alters the expression of inflammatory-related genes in dogsen
local.output.categorydescriptionC1 Refereed Article in a Scholarly Journalen
local.description.statisticsepubsVisitors: 321<br />Views: 338<br />Downloads: 0en
local.search.authorPurushothaman, Dharmaen
local.search.authorBrown, Wendyen
local.search.authorVanselow, Barbaraen
local.search.authorQuinn, Kimen
local.search.authorWu, Shubiaoen
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