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Please use this identifier to cite or link to this item: https://hdl.handle.net/1959.11/12022
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dc.contributor.authorFarrugia, Brooke Len
dc.contributor.authorKeddie, Danielen
dc.contributor.authorGeorge, Graeme Aen
dc.contributor.authorLynam, Emily Cen
dc.contributor.authorBrook, Michael Aen
dc.contributor.authorUpton, Zeeen
dc.contributor.authorDargaville, Tim Aen
dc.date.accessioned2013-02-07T16:55:00Z-
dc.date.issued2012-
dc.identifier.citationJournal of Biomedical Materials Research: Part A, 100A(7), p. 1919-1927en
dc.identifier.issn1552-4965en
dc.identifier.issn1549-3296en
dc.identifier.urihttps://hdl.handle.net/1959.11/12022-
dc.description.abstractThis study investigates the effect of well-defined poly(dimethylsiloxane)-poly(ethylene glycol) (PDMS-PEG) ABA linear block co-oligomers on the proliferation of human dermal fibroblasts. The co-oligomers assessed ranged in molecular weight (MW) from 1335 to 5208 Da and hydrophilic-lipophilic balance (HLB) from 5.9 to 16.6 by varying the number of both PDMS and PEG units. In general, it was found that co-oligomers of low MW or intermediate hydrophilicity significantly reduced fibroblast proliferation. A linear relationship between down-regulation of fibroblast proliferation, and the ratio HLB/MW was observed at concentrations of 0.1 and 1.0 wt % of the oligomers. This enabled the structures with highest efficiency to be determined. These results suggest the possible use of the PEG-PDMS-PEG block co-oligomers as an alternative to silicone gels for hypertrophic scar remediation.en
dc.languageenen
dc.publisherJohn Wiley & Sons, Incen
dc.relation.ispartofJournal of Biomedical Materials Research: Part Aen
dc.titleAn investigation into the effect of amphiphilic siloxane oligomers on dermal fibroblastsen
dc.typeJournal Articleen
dc.identifier.doi10.1002/jbm.a.33310en
dc.subject.keywordsCell Development, Proliferation and Deathen
dc.subject.keywordsBiomaterialsen
dc.subject.keywordsMacromolecular and Materials Chemistryen
local.contributor.firstnameBrooke Len
local.contributor.firstnameDanielen
local.contributor.firstnameGraeme Aen
local.contributor.firstnameEmily Cen
local.contributor.firstnameMichael Aen
local.contributor.firstnameZeeen
local.contributor.firstnameTim Aen
local.subject.for2008090301 Biomaterialsen
local.subject.for2008060103 Cell Development, Proliferation and Deathen
local.subject.for2008030399 Macromolecular and Materials Chemistry not elsewhere classifieden
local.subject.seo2008970106 Expanding Knowledge in the Biological Sciencesen
local.subject.seo2008970103 Expanding Knowledge in the Chemical Sciencesen
local.profile.schoolSchool of Science and Technologyen
local.profile.emaildkeddie@une.edu.auen
local.output.categoryC1en
local.record.placeauen
local.record.institutionUniversity of New Englanden
local.identifier.epublicationsrecordune-20121126-173220en
local.publisher.placeUnited States of Americaen
local.format.startpage1919en
local.format.endpage1927en
local.peerreviewedYesen
local.identifier.volume100Aen
local.identifier.issue7en
local.contributor.lastnameFarrugiaen
local.contributor.lastnameKeddieen
local.contributor.lastnameGeorgeen
local.contributor.lastnameLynamen
local.contributor.lastnameBrooken
local.contributor.lastnameUptonen
local.contributor.lastnameDargavilleen
dc.identifier.staffune-id:dkeddieen
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.identifier.unepublicationidune:12225en
dc.identifier.academiclevelAcademicen
local.title.maintitleAn investigation into the effect of amphiphilic siloxane oligomers on dermal fibroblastsen
local.output.categorydescriptionC1 Refereed Article in a Scholarly Journalen
local.search.authorFarrugia, Brooke Len
local.search.authorKeddie, Danielen
local.search.authorGeorge, Graeme Aen
local.search.authorLynam, Emily Cen
local.search.authorBrook, Michael Aen
local.search.authorUpton, Zeeen
local.search.authorDargaville, Tim Aen
local.uneassociationUnknownen
local.year.published2012en
local.subject.for2020400302 Biomaterialsen
local.subject.for2020310102 Cell development, proliferation and deathen
local.subject.for2020340399 Macromolecular and materials chemistry not elsewhere classifieden
local.subject.seo2020280102 Expanding knowledge in the biological sciencesen
local.subject.seo2020280105 Expanding knowledge in the chemical sciencesen
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