Please use this identifier to cite or link to this item: https://hdl.handle.net/1959.11/10521
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dc.contributor.authorSartin, JLen
dc.contributor.authorKemppainen, RJen
dc.contributor.authorMarple, DNen
dc.contributor.authorCarnes, Ren
dc.contributor.authorDieberg, Gudrunen
dc.contributor.authorOliver, EHen
dc.date.accessioned2012-06-22T15:07:00Z
dc.date.issued1987en
dc.identifier.citationDomestic Animal Endocrinology, 4(1), p. 33-41en
dc.identifier.issn1879-0054en
dc.identifier.issn0739-7240en
dc.identifier.urihttps://hdl.handle.net/1959.11/10521en
dc.description.abstractAdrenergic and perhaps dopaminergic neurons provide inhibitory regulation of growth hormone (GH) secretion in ruminants. This suggests that either serotonergic or other neurons regulate the stimulatory release of GH. The nature of neurotransmitter control of adrenocorticotropin (ACTH) secretion in ruminants has not been determined. Parachlorophenylalanine (PCPA; serotonin synthesis inhibitor), quipazine (serotonin receptor agonist) and cyproheptadine (serotonin receptor antagonist) were utilized in Holstein steers to determine whether serotonin receptors mediate stimulatory actions on GH and ACTH secretion. PCPA (100 mg/kg BW) administered each day at 1900 hr for three successive days did not alter mean GH concentrations, amplitude of GH peaks, nor the number of GH peaks. Likewise, PCPA altered none of these parameters for ACTH. Quipazine injected iv at .1 or .5 mg/kg BW increased plasma GH (P<.05) and ACTH (P<.001) concentrations. There was a dose effect of quipazine on both GH (P<.05) and ACTH (P<.001) secretion. Pretreatment of steers with cyproheptadine (.06 and .6 mg/kg BW) reduced the stimulation of GH by quipazine (P<.0001) and decreased basal GH concentrations (P<.0004). Cyproheptadine at .06 mg/kg BW did not alter quipazineeffects on ACTH, however, the higher dose decreased the peak ACTH response (P<.02) to quipazine. Studies with quipazine and cyproheptadine indicated that serotonergic mechanisms are likely involved in the regulation of GH and ACTH secretion in steers.en
dc.languageenen
dc.publisherElsevier Incen
dc.relation.ispartofDomestic Animal Endocrinologyen
dc.titleEffects of parachlorophenylalanine, quipazine and cyproheptadine on growth hormone and adrenocorticotropin secretion in steersen
dc.typeJournal Articleen
dc.identifier.doi10.1016/0739-7240(87)90036-1en
dc.subject.keywordsAnimal Physiology - Systemsen
local.contributor.firstnameJLen
local.contributor.firstnameRJen
local.contributor.firstnameDNen
local.contributor.firstnameRen
local.contributor.firstnameGudrunen
local.contributor.firstnameEHen
local.subject.for2008060603 Animal Physiology - Systemsen
local.subject.seo2008970106 Expanding Knowledge in the Biological Sciencesen
local.profile.schoolSchool of Science and Technologyen
local.profile.emailgdieberg@une.edu.auen
local.output.categoryC1en
local.record.placeauen
local.record.institutionUniversity of New Englanden
local.identifier.epublicationsrecordune-20120615-152252en
local.publisher.placeUnited States of Americaen
local.format.startpage33en
local.format.endpage41en
local.peerreviewedYesen
local.identifier.volume4en
local.identifier.issue1en
local.contributor.lastnameSartinen
local.contributor.lastnameKemppainenen
local.contributor.lastnameMarpleen
local.contributor.lastnameCarnesen
local.contributor.lastnameDiebergen
local.contributor.lastnameOliveren
dc.identifier.staffune-id:gdiebergen
local.profile.orcid0000-0001-7191-182Xen
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.identifier.unepublicationidune:10716en
dc.identifier.academiclevelAcademicen
local.title.maintitleEffects of parachlorophenylalanine, quipazine and cyproheptadine on growth hormone and adrenocorticotropin secretion in steersen
local.output.categorydescriptionC1 Refereed Article in a Scholarly Journalen
local.description.statisticsepubsVisitors: 272<br />Views: 284<br />Downloads: 0en
local.search.authorSartin, JLen
local.search.authorKemppainen, RJen
local.search.authorMarple, DNen
local.search.authorCarnes, Ren
local.search.authorDieberg, Gudrunen
local.search.authorOliver, EHen
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