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Research UNE (RUNE) is the institutional repository for research outputs of the University of New England, Australia. More information.

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    Publication
    Awaiting Review
    Investigating the impact of resveratrol and quercetin on glymphatic function, blood-brain barrier, and neuroglial health: a systematic review
    (2025-11)
    Renee Grandi
    ;
    Vandana Gulati
    ;
    Md Shahidul Islam
    ;
    Okobi Eko Ekpo
    ;
    Nitin Chitranshi
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    Publication
    Awaiting Review
    The Water Future of the Kingdom of Saudi Arabia: Short- and Medium-Term Challenges
    (2025)
    Christopher M. Fellows
    ;
    Ali A. Al-Hamzah
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    Publication
    Awaiting Review
    Examining attributes of preservice teachers’ vulnerability: Exploring challenging lived experiences during professional experience placements
    (2025)
    Anna Elizabeth Du Plessis
    ;
    Joshua Matthews
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    Casey Mainsbridge
    ;
    Maryam Razmjoee
    ;
    Darin Gorry
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    Publication
    Open Access
    Journal Article
    Demyelination precedes axonal loss in the transneuronal spread of human neurodegenerative disease
    (Oxford University Press, 2019-01-19)
    You, Yuyi
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    Joseph, Chitra
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    Wang, Chenyu
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    Gupta, Vivek
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    Liu, Sidong
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    Yiannikas, Con
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    Chua, Brian E
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    Shen, Ting
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    Dheer, Yogita
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    Invernizzi, Alessandro
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    Borotkanics, Robert
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    Barnett, Michael
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    Graham, Stuart L
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    Klistorner, Alexander

    The spread of neurodegeneration through the human brain network is reported as underlying the progression of neurodegenerative disorders. However, the exact mechanisms remain unknown. The human visual pathway is characterized by its unique hierarchical architecture and, therefore, represents an ideal model to study trans-synaptic degeneration, in contrast to the complexity in neural connectivity of the whole brain. Here we show in two specifically selected patient cohorts, including (i) glaucoma patients with symmetrical bilateral hemifield defects respecting the horizontal meridian (n = 25, 14 females, 64.8 ± 10.1 years; versus 13 normal controls with similar age/sex distributions); and (ii) multiple sclerosis patients without optic radiation lesions (to avoid potential effects of lesions on diffusivity measures) (n = 30, 25 females, 37.9 ± 10.8 years; versus 20 controls), that there are measurable topographic changes in the posterior visual pathways corresponding to the primary optic nerve defects. A significant anisotropic increase of water diffusion was detected in both patient cohorts in the optic radiations, characterized by changes in perpendicular (radial) diffusivity (a measure of myelin integrity) that extended more posteriorly than those observed in parallel (axial) diffusivity (reflecting axonal integrity). In glaucoma, which is not considered a demyelinating disease, the observed increase in radial diffusivity within the optic radiations was validated by topographically linked delay of visual evoked potential latency, a functional measure of demyelination. Radial diffusivity change in the optic radiations was also associated with an asymmetrical reduction in the thickness of the calcarine cortex in glaucoma. In addition, 3 years longitudinal observation of the multiple sclerosis patient cohort revealed an anterograde increase of radial diffusivity in the anterior part of optic radiations which again was retinotopically associated with the primary damage caused by optic neuritis. Finally, in an animal model of optic nerve injury, we observed early glial activation and demyelination in the posterior visual projections, evidenced by the presence of myelin-laden macrophages. This occurred prior to the appearance of amyloid precursor protein accumulation, an indicator of disrupted fast axonal transport. This study demonstrated strong topographical spread of neurodegeneration along recognized neural projections and showed that myelin and glial pathology precedes axonal loss in the process, suggesting that the mechanism of trans-synaptic damage may be at least partially mediated by glial components at the cellular level. The findings may have broad biological and therapeutic implications for other neurodegenerative disorders.

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    Publication
    Open Access
    Journal Article
    Amyloid β Induces Early Changes in the Ribosomal Machinery, Cytoskeletal Organization and Oxidative Phosphorylation in Retinal Photoreceptor Cells
    (Frontiers Research Foundation, 2019-02-22)
    Deng, Liting
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    Pushpitha, Kanishka
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    Joseph, Chitra
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    Gupta, Veer
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    Rajput, Rashi
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    Dheer, Yogita
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    Amirkhani, Ardeshir
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    Kamath, Karthik
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    Pascovici, Dana
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    Wu, Jemma X
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    Salekdeh, Ghasem Hosseini
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    Haynes, Paul A
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    Graham, Stuart L
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    Gupta, Vivek K
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    Mirzaei, Mehdi

    Amyloid β (Aβ) accumulation and its aggregation is characteristic molecular feature of the development of Alzheimer’s disease (AD). More recently, Aβ has been suggested to be associated with retinal pathology associated with AD, glaucoma and drusen deposits in age related macular degeneration (AMD). In this study, we investigated the proteins and biochemical networks that are affected by Aβ in the 661 W photoreceptor cells in culture. Time and dose dependent effects of Aβ on the photoreceptor cells were determined utilizing tandem mass tag (TMT) labeling-based quantitative mass-spectrometric approach. Bioinformatic analysis of the data revealed concentration and time dependent effects of the Aβ peptide stimulation on various key biochemical pathways that might be involved in mediating the toxicity effects of the peptide. We identified increased Tau phosphorylation, GSK3β dysregulation and reduced cell viability in cells treated with Aβ in a dose and time dependent manner. This study has delineated for the first-time molecular networks in photoreceptor cells that are impacted early upon Aβ treatment and contrasted the findings with a longer-term treatment effect. Proteins associated with ribosomal machinery homeostasis, mitochondrial function and cytoskeletal organization were affected in the initial stages of Aβ exposure, which may provide key insights into AD effects on the photoreceptors and specific molecular changes induced by Aβ peptide.

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    Publication
    Conference Publication
    Orgasmic Gushing: where does the fluid come from and how is it produced?
    (Women in Research (WiR), 2005)
    O'Brien, GM
    There are three sexual fluids from women: lubrication (e.g. transudation of fluid across the mucosa of the vagina, and mucus from the greater vestibular glands); female ejaculation (from paraurethral glands); and gushing. Orthodox western medicine and physiology does not yet have a standardized description or explanation for the third, gushing. The present paper proposes that the gushing fluid is a filtrate of plasma, produced by the mechanism known as transudation. This is an additional application for the transudation mechanism, after the well accepted roles in lubrication of the vagina, and in generating serous fluids. The present model proposes that the fluid released in a gush arises from the ventral wall of the vagina due to the presence there of increased surface area of mucosa, dilated arterioles, pressurized venous and lymphatic plexuses, and compression provided by muscle contraction during orgasm.
      65012
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    Publication
    Dataset
    Mapping Long Term Changes in Mangrove Cover and Predictions of Future Change under Different Climate Change Scenarios in the Sundarbans, Bangladesh
    (2018-05-22)
    Ghosh, Manoj Kumer
    ;
    Ground-based readings of temperature and rainfall, satellite imagery, aerial photographs, ground verification data and Digital Elevation Model (DEM) were used in this study. Ground-based meteorological information was obtained from Bangladesh Meteorological Department (BMD) for the period 1977 to 2015 and was used to determine the trends of rainfall and temperature in this thesis. Satellite images obtained from the US Geological Survey (USGS) Center for Earth Resources Observation and Science (EROS) website (www.glovis.usgs.gov) in four time periods were analysed to assess the dynamics of mangrove population at species level. Remote sensing techniques, as a solution to lack of spatial data at a relevant scale and difficulty in accessing the mangroves for field survey and also as an alternative to the traditional methods were used in monitoring of the changes in mangrove species composition, . To identify mangrove forests, a number of satellite sensors have been used, including Landsat TM/ETM/OLI, SPOT, CBERS, SIR, ASTER, and IKONOS and Quick Bird. The use of conventional medium-resolution remote sensor data (e.g., Landsat TM, ASTER, SPOT) in the identification of different mangrove species remains a challenging task. In many developing countries, the high cost of acquiring high- resolution satellite imagery excludes its routine use. The free availability of archived images enables the development of useful techniques in its use and therefor Landsat imagery were used in this study for mangrove species classification. Satellite imagery used in this study includes: Landsat Multispectral Scanner (MSS) of 57 m resolution acquired on 1st February 1977, Landsat Thematic Mapper (TM) of 28.5 m resolution acquired on 5th February 1989, Landsat Enhanced Thematic Mapper (ETM+) of 28.5 m resolution acquired on 28th February 2000 and Landsat Operational Land Imager (OLI) of 30 m resolution acquired on 4th February 2015. To study tidal channel dynamics of the study area, aerial photographs from 1974 and 2011, and a satellite image from 2017 were used. Satellite images from 1974 with good spatial resolution of the area were not available, and therefore aerial photographs of comparatively high and fine resolution were considered adequate to obtain information on tidal channel dynamics. Although high-resolution satellite imagery was available for 2011, aerial photographs were used for this study due to their effectiveness in terms of cost and also ease of comparison with the 1974 photographs. The aerial photographs were sourced from the Survey of Bangladesh (SOB). The Sentinel-2 satellite image from 2017 was downloaded from the European Space Agency (ESA) website (https://scihub.copernicus.eu/). In this research, elevation data acts as the main parameter in the determination of the sea level rise (SLR) impacts on the spatial distribution of the future mangrove species of the Bangladesh Sundarbans. High resolution elevation data is essential for this kind of research where every centimeter counts due to the low-lying characteristics of the study area. The high resolution (less than 1m vertical error) DEM data used in this study was obtained from Water Resources Planning Organization (WRPO), Bangladesh. The elevation information used to construct the DEM was originally collected by a Finnish consulting firm known as FINNMAP in 1991 for the Bangladesh government.
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    Publication
    Conference Publication
    Reinforced Behavioral Variability and Sequence Learning Across Species
    (Association for Behavior Analysis International (ABAI), 2012)
    Doolan, Kathleen
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    ;
    McEwan, James
    Previous research shows that reinforcement of variable responding will facilitate sequence learning in rats (Neuringer, Deiss & Olson, 2000) but may interfere with sequence learning in humans (Maes & van der Goot, 2006). The present study aimed to replicate and extend previous research by assessing the role of behavioral variability in the learning of difficult target sequences across 3 species: humans (n = 60), hens (n = 18) and possums (n = 6). Participants were randomly allocated to one of three experimental conditions (Control, Variable, Any). In the Control conditions sequences were only reinforced if they were the target sequence, in the Variability conditions sequences were concurrently reinforced on a Variable Interval 60-s schedule if the just entered sequence met a variability criterion, and in the Any condition sequences were concurrently reinforced on a Variable Interval 60-s schedule for any sequence entered. The results support previous findings with animals and humans; hens and possums were more likely to learn the target sequence in the Variability condition, and human participants were more likely to learn the target sequence in the Control condition. Possible explanations for differences between the performance of humans and animals on this task will be discussed.
      39890  1
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    Open Access
    Dataset
    The drivers and consequences of change to the physical character of waterholes on an Australian dryland river
    This dataset provides all the raw and analysed data for the thesis titled 'The drivers and consequences of change to the physical character of waterholes on an Australian dryland river'.
    The data has been divided into four folders that are aligned with the data chapters for the thesis. These being: (Ch 2) waterhole mapping, (Ch 3) floodplain gullies, (Ch 4) sediment transport and (Ch 5) fish.
    A README file is provided for each chapter which contains a description of the individual datasets and a list of files that make up each dataset.
    The data in this archive is a combination of data obtained from desktop studies as well as field work on the Darling River (i.e., the fish data).
    Further, fish data were collected on the Darling River between Bourke and Wilcannia. Waterhole mapping was undertaken on the Barwon-Darling between Walgett and Wilcannia. Gully mapping was undertaken on the Barwon-Darling River between Mungindi and Wilcannia. Sediment transport capacity was assessed at five sites between Collarenebri and Tilpa.
      37770  2892
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    Open Access
    Journal Article
    A Review into Effective Classroom Management and Strategies for Student Engagement: Teacher and Student Roles in Today’s Classrooms
    (Redfame Publishing Inc, 2019-12)
    Franklin, Hayley
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    A teacher's role encompasses far more than just imparting curricula outcomes to their students: they need to equip students with the necessary tools to experience social and academic success both inside the classroom and beyond it. Teachers need to empower students with the means to critically analyse the world around them in order to develop into critical independent thinkers. Students need to be proficient in utilising skills associated with higher levels of thinking, that will empower them with the ability to identify, analyse and evaluate the infinite volume of information available through our rapidly changing digital world. Just as teachers need to take responsibility for the various methods of teaching and instruction in the classroom, it is essential for students to take ownership of the learning process, to ensure future success in university environments, where sustained personal effort and metacognitive skills are fundamental to academic success. The object of the review of the literature surrounding the roles of teacher and student, effective classroom management strategies, and successful evidence-based teaching and learning pedagogies, is to assist new and experienced teachers in the promotion of a positive classroom experience for all.
      29888  47825