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Title: A single nucleotide polymorphism in suppressor of cytokine signalling-2 is associated with growth and feed conversion efficiency in pigs
Contributor(s): Chen, Yizhou (author); Piper, E (author); Zhang, Yuandan  (author); Tier, Bruce  (author); Graser, Hans-Ulrich  (author); Luxford, B G (author); Moran, C (author)
Publication Date: 2011
DOI: 10.1111/j.1365-2052.2010.02107.x
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Abstract: Feed efficiency and growth are the most important traits in pig production, and very few genetic markers have been reported to be associated with feed efficiency. The suppressor of cytokine signalling-2 (encoded by SOCS2) is the main negative regulator of somatic growth, and the knockout of SOCS2 and naturally mutant mice have high-growth phenotypes. Porcine SOCS2 was selected as a primary positional candidate for feed efficiency, because it is located on chromosome 5q, in the vicinity of a Quantitative Trait Locus (QTL) region for food conversion ratio in pigs. Here, we report five single nucleotide polymorphisms identified by sequencing of the promoter region and exon 1. One PCR-RFLP assay was designed for genotyping the polymorphism c.1667A > G (GenBank Accession No AY312266). Association analyses were performed in an Australian mapping resource pedigree population (PRDC-US43) for food conversion ratio, backfat, IGF1 level and growth traits and showed significant effects on average daily gain on test (ADG2) (P < 0.01) and marginal association with food conversion ratio (FCR) (P < 0.08).
Publication Type: Journal Article
Source of Publication: Animal Genetics, 42(2), p. 219-221
Publisher: Wiley-Blackwell Publishing Ltd
Place of Publication: England, United Kingdom
ISSN: 0268-9146
Field of Research (FOR): 070201 Animal Breeding
060412 Quantitative Genetics (incl Disease and Trait Mapping Genetics)
Socio-Economic Outcome Codes: 830308 Pigs
Peer Reviewed: Yes
HERDC Category Description: C1 Refereed Article in a Scholarly Journal
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Appears in Collections:Animal Genetics and Breeding Unit (AGBU)
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