Please use this identifier to cite or link to this item:
https://hdl.handle.net/1959.11/9533
Title: | Suppression of feeding, drinking, and locomotion by a putative cannabinoid receptor 'silent antagonist' | Contributor(s): | Gardner, Andrew John (author); Mallet, Paul Emile (author) | Publication Date: | 2006 | DOI: | 10.1016/j.ejphar.2005.11.032 | Handle Link: | https://hdl.handle.net/1959.11/9533 | Abstract: | This study compared the effects of the putative cannabinoid receptor 'silent antagonist' O-2050 with the cannabinoid receptor inverse agonist SR 141716 on food and water consumption, and locomotor activity. Non-deprived male Wistar rats were habituated to the apparatus and testing procedures, then injected intraperitoneally with vehicle, O-2050 (0.03-3.0 mg/kg), or SR 141716 (3.0 mg/kg) prior to 4-h test sessions. Food consumption was significantly reduced by both drugs. Water intake and locomotor activity were significantly reduced only by O-2050. Results support the notion that cannabinoid receptor antagonists suppress feeding behaviour by blocking an endogenous cannabinoid orexigenic signal, rather than by inverse agonism at cannabinoid receptors. However, further studies are needed to confirm the status of O-2050 as a cannabinoid CB₁ receptor antagonist devoid of inverse agonist properties. | Publication Type: | Journal Article | Source of Publication: | European Journal of Pharmacology, 530(1-2), p. 103-106 | Publisher: | Elsevier BV | Place of Publication: | Netherlands | ISSN: | 1879-0712 0014-2999 |
Fields of Research (FoR) 2008: | 170101 Biological Psychology (Neuropsychology, Psychopharmacology, Physiological Psychology) | Socio-Economic Objective (SEO) 2008: | 920111 Nervous System and Disorders | Peer Reviewed: | Yes | HERDC Category Description: | C1 Refereed Article in a Scholarly Journal |
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Appears in Collections: | Journal Article |
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