Please use this identifier to cite or link to this item:
https://hdl.handle.net/1959.11/9507
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DC Field | Value | Language |
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dc.contributor.author | Smart, Neil | en |
dc.contributor.author | Kwok, Nigel | en |
dc.contributor.author | Holland, David J | en |
dc.contributor.author | Jayasinghe, Rohan | en |
dc.contributor.author | Giallauria, Francesco | en |
dc.date.accessioned | 2012-02-21T17:37:00Z | - |
dc.date.issued | 2011 | - |
dc.identifier.citation | Clinical Medicine Insights: Cardiology, v.5, p. 55-66 | en |
dc.identifier.issn | 1179-5468 | en |
dc.identifier.uri | https://hdl.handle.net/1959.11/9507 | - |
dc.description.abstract | Bucindolol is a non-selective ß-adrenergic receptor blocker with a-1 blocker properties and mild intrinsic sympatholytic activity. The Beta-Blocker Evaluation of Survival Trial (BEST), which is the largest clinical trial of bucindolol in patients with heart failure, was terminated prematurely and failed to show an overall mortality benefit. However, benefits on cardiac mortality and re-hospitalization rates were observed in the BEST trial. Bucindolol has not shown benefits in African Americans, those with significantly low ejection fraction and those in NYHA class IV heart failure. These observations could be due to the exaggerated sympatholytic response to bucindolol in these sub-groups that may be mediated by genetic polymorphisms or changes in gene regulation due to advanced heart failure. This paper provides a timely clinical update on the use of bucindolol in chronic heart failure. | en |
dc.language | en | en |
dc.publisher | Libertas Academica Ltd | en |
dc.relation.ispartof | Clinical Medicine Insights: Cardiology | en |
dc.title | Bucindolol: A Pharmacogenomic Perspective on Its Use in Chronic Heart Failure | en |
dc.type | Journal Article | en |
dc.identifier.doi | 10.4137/CMC.S4309 | en |
dcterms.accessRights | Gold | en |
dc.subject.keywords | Clinical Pharmacology and Therapeutics | en |
dc.subject.keywords | Cardiology (incl Cardiovascular Diseases) | en |
local.contributor.firstname | Neil | en |
local.contributor.firstname | Nigel | en |
local.contributor.firstname | David J | en |
local.contributor.firstname | Rohan | en |
local.contributor.firstname | Francesco | en |
local.subject.for2008 | 110201 Cardiology (incl Cardiovascular Diseases) | en |
local.subject.for2008 | 111502 Clinical Pharmacology and Therapeutics | en |
local.subject.seo2008 | 920103 Cardiovascular System and Diseases | en |
local.profile.school | School of Science and Technology | en |
local.profile.school | Human Biology and Physiology | en |
local.profile.school | Human Biology and Physiology | en |
local.profile.school | Human Biology and Physiology | en |
local.profile.school | Human Biology and Physiology | en |
local.profile.email | nsmart2@une.edu.au | en |
local.output.category | C1 | en |
local.record.place | au | en |
local.record.institution | University of New England | en |
local.identifier.epublicationsrecord | une-20111212-12293 | en |
local.publisher.place | New Zealand | en |
local.format.startpage | 55 | en |
local.format.endpage | 66 | en |
local.identifier.scopusid | 84860398529 | en |
local.peerreviewed | Yes | en |
local.identifier.volume | 5 | en |
local.title.subtitle | A Pharmacogenomic Perspective on Its Use in Chronic Heart Failure | en |
local.access.fulltext | Yes | en |
local.contributor.lastname | Smart | en |
local.contributor.lastname | Kwok | en |
local.contributor.lastname | Holland | en |
local.contributor.lastname | Jayasinghe | en |
local.contributor.lastname | Giallauria | en |
dc.identifier.staff | une-id:nsmart2 | en |
local.profile.orcid | 0000-0002-8290-6409 | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.identifier.unepublicationid | une:9698 | en |
dc.identifier.academiclevel | Academic | en |
local.title.maintitle | Bucindolol | en |
local.output.categorydescription | C1 Refereed Article in a Scholarly Journal | en |
local.search.author | Smart, Neil | en |
local.search.author | Kwok, Nigel | en |
local.search.author | Holland, David J | en |
local.search.author | Jayasinghe, Rohan | en |
local.search.author | Giallauria, Francesco | en |
local.uneassociation | Unknown | en |
local.year.published | 2011 | en |
Appears in Collections: | Journal Article |
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