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Title: Bucindolol: A Pharmacogenomic Perspective on Its Use in Chronic Heart Failure
Contributor(s): Smart, Neil  (author)orcid ; Kwok, Nigel (author); Holland, David J (author); Jayasinghe, Rohan (author); Giallauria, Francesco (author)
Publication Date: 2011
Open Access: Yes
DOI: 10.4137/CMC.S4309Open Access Link
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Abstract: Bucindolol is a non-selective ß-adrenergic receptor blocker with a-1 blocker properties and mild intrinsic sympatholytic activity. The Beta-Blocker Evaluation of Survival Trial (BEST), which is the largest clinical trial of bucindolol in patients with heart failure, was terminated prematurely and failed to show an overall mortality benefit. However, benefits on cardiac mortality and re-hospitalization rates were observed in the BEST trial. Bucindolol has not shown benefits in African Americans, those with significantly low ejection fraction and those in NYHA class IV heart failure. These observations could be due to the exaggerated sympatholytic response to bucindolol in these sub-groups that may be mediated by genetic polymorphisms or changes in gene regulation due to advanced heart failure. This paper provides a timely clinical update on the use of bucindolol in chronic heart failure.
Publication Type: Journal Article
Source of Publication: Clinical Medicine Insights: Cardiology, v.5, p. 55-66
Publisher: Libertas Academica Ltd
Place of Publication: New Zealand
ISSN: 0008-6312
Field of Research (FOR): 110201 Cardiology (incl Cardiovascular Diseases)
111502 Clinical Pharmacology and Therapeutics
Socio-Economic Outcome Codes: 920103 Cardiovascular System and Diseases
Peer Reviewed: Yes
HERDC Category Description: C1 Refereed Article in a Scholarly Journal
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