Please use this identifier to cite or link to this item:
https://hdl.handle.net/1959.11/9489
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Smart, Neil | en |
dc.contributor.author | Larsen, Alf Inge | en |
dc.contributor.author | Le Maitre, John P | en |
dc.contributor.author | Ferraz, Almir S | en |
dc.date.accessioned | 2012-02-21T14:33:00Z | - |
dc.date.issued | 2011 | - |
dc.identifier.citation | Cardiology Research and Practice, v.2011, p. 1-6 | en |
dc.identifier.issn | 2090-0597 | en |
dc.identifier.issn | 2090-8016 | en |
dc.identifier.uri | https://hdl.handle.net/1959.11/9489 | - |
dc.description.abstract | Background: We pooled data from four studies, to establish whether exercise training programs were able to modulate systemic cytokine levels of tumour necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6). A second aim was to establish if differences in ExT regimens are related to degree of change in cytokines and peak VO₂. Methods: Data from four centres relating to training protocol, exercise capacity, and cytokine measures (TNF-alpha and IL-6) were pooled for analysis. Results: Data for 106 CHF patients were collated (98 men, age 62 ± 10 yrs, wt 79 ± 14 Kg). Patients were moderately impaired (peak VO₂ 16.9 ± 4.4 mls/kg/min), with moderate LV systolic dysfunction (EF 30 ± 6.9%), 78% (83) had ischaemic cardiomyopathy. After ExT, peak VO₂ increased 1.4 ± 3.4 ml/kg/min (P<.001), serum TNF-alpha decreased 1.9 ± 8.6 pg/ml (P=.02) and IL-6 was not significantly changed (0.5 ± 5.4 pg/ml, P=.32) for the whole group. Baseline and post-training peak VO₂ changes were not correlated with change in cytokine levels. Conclusions: Exercise training reduces levels TNF-alpha but not IL-6 in CHF. However, across a heterogenic patient group, change in peak VO₂ was not correlated with alterations in cytokine levels. While greater exercise volume (hours) was superior in improving peak VO₂, no particular characteristic of ExT regimes appeared superior in effecting change in serum cytokines. | en |
dc.language | en | en |
dc.publisher | Hindawi Limited | en |
dc.relation.ispartof | Cardiology Research and Practice | en |
dc.title | Effect of Exercise Training on Interleukin-6, Tumour Necrosis Factor Alpha and Functional Capacity in Heart Failure | en |
dc.type | Journal Article | en |
dc.identifier.doi | 10.4061/2011/532620 | en |
dcterms.accessRights | Gold | en |
dc.subject.keywords | Exercise Physiology | en |
local.contributor.firstname | Neil | en |
local.contributor.firstname | Alf Inge | en |
local.contributor.firstname | John P | en |
local.contributor.firstname | Almir S | en |
local.subject.for2008 | 110602 Exercise Physiology | en |
local.subject.seo2008 | 920103 Cardiovascular System and Diseases | en |
local.profile.school | School of Science and Technology | en |
local.profile.school | Human Biology and Physiology | en |
local.profile.school | Human Biology and Physiology | en |
local.profile.school | Human Biology and Physiology | en |
local.profile.email | nsmart2@une.edu.au | en |
local.output.category | C1 | en |
local.record.place | au | en |
local.record.institution | University of New England | en |
local.identifier.epublicationsrecord | une-20111212-111845 | en |
local.publisher.place | United States of America | en |
local.identifier.runningnumber | Article ID 532620 | en |
local.format.startpage | 1 | en |
local.format.endpage | 6 | en |
local.identifier.scopusid | 79959431694 | en |
local.peerreviewed | Yes | en |
local.identifier.volume | 2011 | en |
local.access.fulltext | Yes | en |
local.contributor.lastname | Smart | en |
local.contributor.lastname | Larsen | en |
local.contributor.lastname | Le Maitre | en |
local.contributor.lastname | Ferraz | en |
dc.identifier.staff | une-id:nsmart2 | en |
local.profile.orcid | 0000-0002-8290-6409 | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.identifier.unepublicationid | une:9680 | en |
dc.identifier.academiclevel | Academic | en |
local.title.maintitle | Effect of Exercise Training on Interleukin-6, Tumour Necrosis Factor Alpha and Functional Capacity in Heart Failure | en |
local.output.categorydescription | C1 Refereed Article in a Scholarly Journal | en |
local.search.author | Smart, Neil | en |
local.search.author | Larsen, Alf Inge | en |
local.search.author | Le Maitre, John P | en |
local.search.author | Ferraz, Almir S | en |
local.uneassociation | Unknown | en |
local.year.published | 2011 | en |
Appears in Collections: | Journal Article |
Files in This Item:
File | Description | Size | Format |
---|
SCOPUSTM
Citations
47
checked on Mar 16, 2024
Page view(s)
1,038
checked on Oct 22, 2023
Download(s)
2
checked on Oct 22, 2023
Items in Research UNE are protected by copyright, with all rights reserved, unless otherwise indicated.