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Title: Novel endoperoxides: Synthesis and activity against 'Candida' species
Contributor(s): Macreadie, Peter (author); Avery, Thomas D (author); Greatrex, Ben  (author)orcid ; Taylor, Dennis K (author); Macreadie, Ian G (author)
Publication Date: 2006
DOI: 10.1016/j.bmcl.2005.10.101
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Abstract: Fifteen new endoperoxides have been synthesised and tested for activity against pathogenic 'Candida' species. These endoperoxides can be prepared in high yields, in one to three steps, from inexpensive starting materials. Despite chemical and structural similarities, their inhibitory activity against 'Candida' growth varied greatly from one endoperoxide to another, and one species to another. This study of susceptibility to endoperoxide compounds presented here may lead to the development of potent new antifungal agents.
Publication Type: Journal Article
Source of Publication: Bioorganic & Medicinal Chemistry Letters, 16(4), p. 920-922
Publisher: Pergamon
Place of Publication: United Kingdom
ISSN: 1464-3405
Field of Research (FOR): 030401 Biologically Active Molecules
030503 Organic Chemical Synthesis
Socio-Economic Objective (SEO): 970103 Expanding Knowledge in the Chemical Sciences
970106 Expanding Knowledge in the Biological Sciences
Peer Reviewed: Yes
HERDC Category Description: C1 Refereed Article in a Scholarly Journal
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Appears in Collections:Journal Article
School of Rural Medicine

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