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Title: Design of endoperoxides with anti-'Candida' activity
Contributor(s): Avery, Thomas D (author); Macreadie, Peter I (author); Greatrex, Ben  (author)orcid ; Robinson, Tony V (author); Taylor, Dennis K (author); Macreadie, Ian G (author)
Publication Date: 2007
DOI: 10.1016/j.bmc.2006.10.021
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Abstract: Broad antifungal structure–activity relationships governing epoxy-endoperoxides 2 and 3 and their parent endoperoxides 1 are reported. Their inhibitory activity against 'Candida albicans' in conjunction with hemolytic activity and/or growth inhibition of cultured mammalian cells are reported. This information provided guidance for the further development of endoperoxide and epoxy-endoperoxides as topical antifungal agents.
Publication Type: Journal Article
Source of Publication: Bioorganic & Medicinal Chemistry, 15(1), p. 36-42
Publisher: Pergamon
Place of Publication: United Kingdom
ISSN: 1464-3391
Field of Research (FOR): 030503 Organic Chemical Synthesis
030401 Biologically Active Molecules
Socio-Economic Outcome Codes: 970103 Expanding Knowledge in the Chemical Sciences
970106 Expanding Knowledge in the Biological Sciences
Peer Reviewed: Yes
HERDC Category Description: C1 Refereed Article in a Scholarly Journal
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Appears in Collections:Journal Article
School of Rural Medicine

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