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https://hdl.handle.net/1959.11/9264| Title: | Design of endoperoxides with anti-'Candida' activity | Contributor(s): | Avery, Thomas D (author); Macreadie, Peter I (author); Greatrex, Ben (author) ; Robinson, Tony V (author); Taylor, Dennis K (author); Macreadie, Ian G (author) |
Publication Date: | 2007 | DOI: | 10.1016/j.bmc.2006.10.021 | Handle Link: | https://hdl.handle.net/1959.11/9264 | Abstract: | Broad antifungal structure–activity relationships governing epoxy-endoperoxides 2 and 3 and their parent endoperoxides 1 are reported. Their inhibitory activity against 'Candida albicans' in conjunction with hemolytic activity and/or growth inhibition of cultured mammalian cells are reported. This information provided guidance for the further development of endoperoxide and epoxy-endoperoxides as topical antifungal agents. | Publication Type: | Journal Article | Source of Publication: | Bioorganic & Medicinal Chemistry, 15(1), p. 36-42 | Publisher: | Pergamon Press | Place of Publication: | United Kingdom | ISSN: | 1464-3391 0968-0896 |
Fields of Research (FoR) 2008: | 030503 Organic Chemical Synthesis 030401 Biologically Active Molecules |
Socio-Economic Objective (SEO) 2008: | 970103 Expanding Knowledge in the Chemical Sciences 970106 Expanding Knowledge in the Biological Sciences |
Peer Reviewed: | Yes | HERDC Category Description: | C1 Refereed Article in a Scholarly Journal |
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| Appears in Collections: | Journal Article School of Rural Medicine |
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