Please use this identifier to cite or link to this item: https://hdl.handle.net/1959.11/9216
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dc.contributor.authorOlejnik, Jeanette Alisonen
dc.contributor.authorHill, Jonen
dc.contributor.authorHinch, Geoffreyen
dc.date.accessioned2012-01-16T14:59:00Z
dc.date.created2008en
dc.date.issued2009en
dc.identifier.urihttps://hdl.handle.net/1959.11/9216en
dc.description.abstractGerm cell transplantation has been shown to be a useful technique for studying spermatogenesis in rodents. In livestock species, the germ cell transplant technique could be used to produce transgenic animals and as a reproductive technology in extensive production systems. One of the contributing factors to poor success thus far has been poor recipient preparation, such as depletion of endogenous germ cells. This thesis investigated four depletion methods known to affect germ cells; heat, cold, chemotherapy (Busulfan) and irradiation. ... This thesis has found that testicular irradiation is the most successful method tested to deplete endogenous spermatogonia in the sheep testis. In addition, irradiated testes can support both endogenous and donor derived spermatogenesis. It seems that irradiation at high doses (15Gy) at the peri-pubertal to pubertal stage of testicular development can produce suitable recipients for germ cell transplantation and therefore is a potential methodology to increase the efficiency of germ cell transplants in livestock species.en
dc.languageenen
dc.titleTesticular Germ Cell Depletion and Transplantation in Cattle and Sheepen
dc.typeThesis Doctoralen
dc.subject.keywordsAnimal Physiology - Cellen
local.contributor.firstnameJeanette Alisonen
local.contributor.firstnameJonen
local.contributor.firstnameGeoffreyen
local.subject.for2008060602 Animal Physiology - Cellen
local.subject.seo2008830301 Beef Cattleen
local.subject.seo630103 Beef Cattleen
dcterms.RightsStatementCopyright 2008 - Jeanette Alison Olejniken
dc.date.conferred2009en
local.thesis.degreelevelDoctoralen
local.thesis.degreenameDoctor of Philosophyen
local.contributor.grantorUniversity of New Englanden
local.profile.schoolSchool of Environmental and Rural Scienceen
local.profile.schoolSchool of Environmental and Rural Scienceen
local.profile.emailJeanette.olejnik@csiro.auen
local.profile.emailJon.hill@csiro.auen
local.profile.emailghinch@une.edu.auen
local.output.categoryT2en
local.record.placeauen
local.record.institutionUniversity of New Englanden
local.identifier.epublicationsrecordune_thesis-20090106-18212en
local.contributor.lastnameOlejniken
local.contributor.lastnameHillen
local.contributor.lastnameHinchen
dc.identifier.staffune-id:ghinchen
local.profile.orcid0000-0003-4731-865Xen
local.profile.roleauthoren
local.profile.rolesupervisoren
local.profile.rolesupervisoren
local.identifier.unepublicationidune:9407en
dc.identifier.academiclevelAcademicen
dc.identifier.academiclevelAcademicen
local.title.maintitleTesticular Germ Cell Depletion and Transplantation in Cattle and Sheepen
local.output.categorydescriptionT2 Thesis - Doctorate by Researchen
local.description.statisticsepubsVisitors: 161<br />Views: 172<br />Downloads: 0en
local.thesis.borndigitalyesen
local.search.authorOlejnik, Jeanette Alisonen
local.search.supervisorHill, Jonen
local.search.supervisorHinch, Geoffreyen
Appears in Collections:School of Environmental and Rural Science
Thesis Doctoral
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