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https://hdl.handle.net/1959.11/9133
Title: | The Role of Leptin in Reproduction and Fertility | Contributor(s): | McFarlane, Jim (author) ; Kauter, Kate (author); Panwar, Shalini (author) | Publication Date: | 2008 | Handle Link: | https://hdl.handle.net/1959.11/9133 | Abstract: | Leptin was originally identified as a peripheral satiety signal made by fat cells and it was proposed that as fat accumulates leptin is secreted proportionally. Leptin then crosses the blood brain barrier and signals to the hypothalamus suppressing appetite and increasing energy expenditure as it rises. It is evident that if the leptin gene or its receptor is disrupted them morbid obesity occurs. However, obesity in humans is very rarely caused by a disruption of the leptin gene or its receptor, and in many species a good correlation exists between leptin concentrations in plasma with the degree of obesity. This early finding was unexpected and led to the leptin resistance hypothesis. Further studies have revealed that leptin actually appears to be almost ubiquitously expressed in many tissues. Unfortunately despite the accumulation of a vast literature leptin still appears to be regarded as a peripheral satiety signal although the data to support this hypothesis is not substantial. | Publication Type: | Conference Publication | Conference Details: | ACVSc 2008 Conference: Australian College of Veterinary Scientists 2008 Annual Conference, Surfers Paradise, Australia, 3rd - 5th July, 2008 | Source of Publication: | Australian College of Veterinary Scientists 2008 Annual Conference - Equine Chapter Conference Program and Proceedings, p. 100-102 | Publisher: | Australian College of Veterinary Scientists | Place of Publication: | online | Fields of Research (FoR) 2008: | 060699 Physiology not elsewhere classified | Socio-Economic Objective (SEO) 2008: | 970111 Expanding Knowledge in the Medical and Health Sciences | HERDC Category Description: | E3 Extract of Scholarly Conference Publication | Publisher/associated links: | http://equine.anzcvs.org.au/equine/science_week/2008_proceedings/ |
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Appears in Collections: | Conference Publication |
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