Please use this identifier to cite or link to this item: https://hdl.handle.net/1959.11/9074
Title: Gene expression profiling of bovine skeletal muscle in response to and during recovery from chronic and severe undernutrition
Contributor(s): Lehnert, SA (author); Byrne, KA (author); Reverter, Antonio (author); Nattrass, GS (author); Greenwood, Paul (author); Wang, YH (author); Hudson, NJ (author); Harper, GS (author)
Publication Date: 2006
DOI: 10.2527/jas.2006-192
Handle Link: https://hdl.handle.net/1959.11/9074
Abstract: Gene expression profiles of LM from beef cattle that underwent significant postweaning undernutrition were studied using complementary DNA (cDNA) microarrays. After 114 d of undernutrition, the RNA from LM showed 2- to 6-fold less expression of many genes from the classes of muscle structural proteins, muscle metabolic enzymes, and extracellular matrix compared with animals on a rapid growth diet. The expression levels of these genes had mostly returned to pretreatment levels after 84 d of realimentation. The gene expression changes associated with undernutrition and BW loss showed an emphasis on downregulation of gene expression specific to fast-twitch fibers, typical of starving mammals, with a preferential atrophy of glycolytic fast-twitch fibers. We also identified a small group of genes that showed 2- to 5-fold elevated expression in LM after 114 d of undernutrition. Putative roles for these genes in atrophying skeletal muscle are regulation of myogenic differentiation (CSRP3), maintenance of mesenchymal stem cells (CYR61), modulation of membrane function (TM4SF2), prevention of oxidative damage (SESN1), and regulation of muscle protein degradation (SQSTM1). A significant increase in stearoyl-CoA desaturase (SCD) gene expression was observed in atrophying muscle, suggesting either that increased fatty acid synthesis is part of the tissue response to caloric restriction, or that SCD plays another role in energy metabolism in the mixed cellular environment of bovine skeletal muscle.
Publication Type: Journal Article
Source of Publication: Journal of Animal Science, 84(12), p. 3239-3250
Publisher: American Society of Animal Science
Place of Publication: United States of America
ISSN: 1525-3163
0021-8812
Fields of Research (FoR) 2008: 070702 Veterinary Anatomy and Physiology
070204 Animal Nutrition
Socio-Economic Objective (SEO) 2008: 830302 Dairy Cattle
830301 Beef Cattle
Peer Reviewed: Yes
HERDC Category Description: C1 Refereed Article in a Scholarly Journal
Appears in Collections:Journal Article

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