Please use this identifier to cite or link to this item: https://hdl.handle.net/1959.11/9060
Title: Variation in protein abundance profiles in the 'M. semitendinosus' of lambs bred from sires selected on the basis of growth and muscling potential
Contributor(s): McDonagh, M B (author); Ferguson, K L (author); Bacic, A (author); Gardner, Graham E (author); Hegarty, Roger  (author)
Publication Date: 2006
DOI: 10.1071/AR04277
Handle Link: https://hdl.handle.net/1959.11/9060
Abstract: Relative abundance of proteins localised in the nuclear-enriched, total cell membrane and cytosolic fractions of the 'semitendinosus' muscle was compared between lambs bred from control (C), high muscling (M), and high growth rate (G) sires. In total, 31 proteins were identified whose abundance was differentially regulated between sire type. Differences in hind-limb muscle development between M lambs and C and G lambs were reflected in levels of proteins that regulate or function in cellular mechanisms of protein and energy metabolism. Despite no apparent difference in hind-limb muscle growth in G lambs compared to C, G lambs exhibited marked differences in proteins involved in regulation and function of energy metabolism. These results detail pathways that can be specifically targeted to enhance muscle accretion and growth in lambs. The development of means to manipulate these cellular mechanisms may yield greater gains in muscle accretion and growth rate than breeding on the basis for genetic capacity alone.
Publication Type: Journal Article
Source of Publication: Australian Journal of Agricultural Research, 57(6), p. 671-682
Publisher: CSIRO Publishing
Place of Publication: Australia
ISSN: 1444-9838
0004-9409
1836-5795
1836-0947
Fields of Research (FoR) 2008: 070202 Animal Growth and Development
Socio-Economic Objective (SEO) 2008: 830310 Sheep - Meat
Peer Reviewed: Yes
HERDC Category Description: C1 Refereed Article in a Scholarly Journal
Appears in Collections:Journal Article
School of Environmental and Rural Science

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