X-ray scattering for classifying tissue types associated with breast disease

Title
X-ray scattering for classifying tissue types associated with breast disease
Publication Date
2008
Author(s)
Sidhu, S
Siu, KKW
Falzon, Gregory
( author )
OrcID: https://orcid.org/0000-0002-1989-9357
Email: gfalzon2@une.edu.au
UNE Id une-id:gfalzon2
Nazaretian, S
Hart, SA
Fox, JG
Susil, BJ
Lewis, RA
Type of document
Journal Article
Language
en
Entity Type
Publication
Publisher
American Association of Physicists in Medicine
Place of publication
United States of America
DOI
10.1118/1.2977667
UNE publication id
une:8898
Abstract
Collagen types I and III can be characterized at the molecular level (at the tens to hundreds of nanometers scale) using small angle x-ray scattering (SAXS). Although collagen fibril structural parameters at this length scale have shown differences between diseased and nondiseased breast tissues, a comprehensive analysis involving a multitude of features with a large (>50) patient cohort has not previously been investigated. Breast tissue samples were excised from 80 patients presenting with either a breast lump or reduction mammoplasty. From these, invasive carcinoma, benign tissue, and normal parenchyma were analyzed. Parameters related to collagen structure, including longitudinal (axial) and lateral (equatorial) features, polar angle features, total scattering intensity, and tissue heterogeneity effects, were extracted from the SAXS patterns and examined. The amplitude of the third-order axial peak and the total scattering intensity (amorphous scatter) showed the most separation between tissue groups and a classification model using these two parameters demonstrated an accuracy of over 95% between invasive carcinoma and mammoplasty patients. Normal tissue taken from disease-free patients (mammoplasty) and normal tissue taken from patients with presence of disease showed significant differences, suggesting that SAXS may provide different diagnostic information from that of conventional histopathology.
Link
Citation
Medical Physics, 35(10), p. 4660-4670
ISSN
2473-4209
0094-2405
Start page
4660
End page
4670

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