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https://hdl.handle.net/1959.11/8685
Title: | Classification of breast tissue using a laboratory system for small-angle x-ray scattering (SAXS) | Contributor(s): | Sidhu, S (author); Falzon, Gregory (author) ; Hart, SA (author); Fox, JG (author); Lewis, RA (author); Siu, KKW (author) | Publication Date: | 2011 | Open Access: | Yes | DOI: | 10.1088/0031-9155/56/21/002 | Handle Link: | https://hdl.handle.net/1959.11/8685 | Abstract: | Structural changes in breast tissue at the nanometre scale have been shown to differentiate between tissue types using synchrotron SAXS techniques. Classification of breast tissues using information acquired from a laboratory SAXS camera source could possibly provide a means of adopting SAXS as a viable diagnostic procedure. Tissue samples were obtained from surgical waste from 66 patients and structural components of the tissues were examined between q = 0.25 and 2.3 nm⁻¹. Principal component analysis showed that the amplitude of the fifth-order axial Bragg peak, the magnitude of the integrated intensity and the full-width at half-maximum of the fat peak were significantly different between tissue types. A discriminant analysis showed that excellent classification can be achieved; however, only 30% of the tissue samples provided the 16 variables required for classification. This suggests that the presence of disease is represented by a combination of factors, rather than one specific trait. A closer examination of the amorphous scattering intensity showed not only a trend of increased scattering intensity with disease severity, but also a corresponding decrease in the size of the scatterers contributing to this intensity. | Publication Type: | Journal Article | Source of Publication: | Physics in Medicine and Biology, 56(21), p. 6779-6791 | Publisher: | Institute of Physics Publishing Ltd | Place of Publication: | United Kingdom | ISSN: | 1361-6560 0031-9155 |
Fields of Research (FoR) 2008: | 111202 Cancer Diagnosis 029903 Medical Physics |
Socio-Economic Objective (SEO) 2008: | 970111 Expanding Knowledge in the Medical and Health Sciences 920102 Cancer and Related Disorders |
Peer Reviewed: | Yes | HERDC Category Description: | C1 Refereed Article in a Scholarly Journal |
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Appears in Collections: | Journal Article School of Science and Technology |
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