Classification of breast tissue using a laboratory system for small-angle x-ray scattering (SAXS)

Title
Classification of breast tissue using a laboratory system for small-angle x-ray scattering (SAXS)
Publication Date
2011
Author(s)
Sidhu, S
Falzon, Gregory
( author )
OrcID: https://orcid.org/0000-0002-1989-9357
Email: gfalzon2@une.edu.au
UNE Id une-id:gfalzon2
Hart, SA
Fox, JG
Lewis, RA
Siu, KKW
Type of document
Journal Article
Language
en
Entity Type
Publication
Publisher
Institute of Physics Publishing Ltd
Place of publication
United Kingdom
DOI
10.1088/0031-9155/56/21/002
UNE publication id
une:8875
Abstract
Structural changes in breast tissue at the nanometre scale have been shown to differentiate between tissue types using synchrotron SAXS techniques. Classification of breast tissues using information acquired from a laboratory SAXS camera source could possibly provide a means of adopting SAXS as a viable diagnostic procedure. Tissue samples were obtained from surgical waste from 66 patients and structural components of the tissues were examined between q = 0.25 and 2.3 nm⁻¹. Principal component analysis showed that the amplitude of the fifth-order axial Bragg peak, the magnitude of the integrated intensity and the full-width at half-maximum of the fat peak were significantly different between tissue types. A discriminant analysis showed that excellent classification can be achieved; however, only 30% of the tissue samples provided the 16 variables required for classification. This suggests that the presence of disease is represented by a combination of factors, rather than one specific trait. A closer examination of the amorphous scattering intensity showed not only a trend of increased scattering intensity with disease severity, but also a corresponding decrease in the size of the scatterers contributing to this intensity.
Link
Citation
Physics in Medicine and Biology, 56(21), p. 6779-6791
ISSN
1361-6560
0031-9155
Start page
6779
End page
6791

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