Please use this identifier to cite or link to this item: https://hdl.handle.net/1959.11/8603
Title: Regional differences in naloxone modulation of Δ9-THC induced Fos expression in rat brain
Contributor(s): Allen, Kelly V (author); McGreggor, I S (author); Hunt, G E (author); Singh, Malini E (author); Mallet, Paul Emile (author)
Publication Date: 2003
DOI: 10.1016/S0028-3908(02)00364-7
Handle Link: https://hdl.handle.net/1959.11/8603
Abstract: Recent behavioral and pharmacological research shows extensive interplay between cannabanoid and opioid neurochemical systems. Here we examined the neuroanatomical basis of this interaction using 'c-fos' immunohistochemistry. We compared Fos immunoreactivity in groups of male albino Wistar rats treated with vehicle, Δ9-tetrahydrocannabinol (THC, 10mg/kg, i.p.), naloxone (10mg/kg, i.p.) or THC and naloxone in combination. Locomotor activity was depressed in both THC treatment groups and moderately inhibited in rats given naloxone alone. Results showed that naloxone inhibited THC-induced Fos immunoreactivity in several key brain regions including the ventral tegmental area, ventromedial and dorsomedial hypothalamus, central caudate-putamen and ventrolateral periaqueductal grey. Conversely, naloxone and THC had an additive effect on Fos immunoreactivity in the central nucleus of the amygdala, the bed nucleus of the stria terminalis (lateral division), the insular cortex, and the paraventricular nucleus of the thalmus. These findings complement earlier pharmacological results showing potent modulation of cannabinoid-induced analgesia, appetite and reward by opioids. The inhibitory effects of naloxone on THC-induced ventral tegmentum, hypothalmic and periaqueductal grey Fos expression point to these structures as key sites involved in cannabinoid-opioid interactions.
Publication Type: Journal Article
Source of Publication: Neuropharmacology, 44(2), p. 264-274
Publisher: Elsevier Ltd
Place of Publication: United Kingdom
ISSN: 1873-7064
0028-3908
Fields of Research (FoR) 2008: 170101 Biological Psychology (Neuropsychology, Psychopharmacology, Physiological Psychology)
Socio-Economic Objective (SEO) 2008: 920414 Substance Abuse
Peer Reviewed: Yes
HERDC Category Description: C1 Refereed Article in a Scholarly Journal
Appears in Collections:Journal Article

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