Please use this identifier to cite or link to this item: https://hdl.handle.net/1959.11/8584
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dc.contributor.authorWood, REen
dc.contributor.authorSanderson, BEen
dc.contributor.authorAskew, CDen
dc.contributor.authorWalker, PJen
dc.contributor.authorGreen, Simonen
dc.contributor.authorStewart, IBen
dc.date.accessioned2011-09-27T11:24:00Z
dc.date.issued2006en
dc.identifier.citationClinical Science, 111(6), p. 401-409en
dc.identifier.issn1470-8736en
dc.identifier.issn0143-5221en
dc.identifier.urihttps://hdl.handle.net/1959.11/8584en
dc.description.abstractExpansion of the capillary network, or angiogenesis, occurs following endurance training. This process, which is reliant on the presence of VEGF (vascular endothelial growth factor), is an adaptation to a chronic mismatch between oxygen demand and supply. Patients with IC (intermittent claudication) experience pain during exercise associated with an inadequate oxygen delivery to the muscles. Therefore the aims of the present study were to examine the plasma VEGF response to acute exercise, and to establish whether exercise training alters this response in patients with IC. In Part A, blood was collected from patients with IC (n=18) before and after (+20 and +60 min post-exercise) a maximal walking test to determine the plasma VEGF response to acute exercise. VEGF was present in the plasma of patients (45.11±29.96 pg/ml) and was unchanged in response to acute exercise. Part B was a training study to determine whether exercise training altered the VEGF response to acute exercise. Patients were randomly assigned to a treatment group (TMT; n=7) that completed 6 weeks of high-intensity treadmill training, or to a control group (CON; n=6). All patients completed a maximal walking test before and after the intervention, with blood samples drawn as for Part A. Training had no effect on plasma VEGF at rest or in response to acute exercise, despite a significant increase in maximal walking time in the TMT group (915±533 to 1206±500 s; P=0.009) following the intervention. The absence of a change in plasma VEGF may reflect altered VEGF binding at the endothelium, although this cannot be confirmed by the present data.en
dc.languageenen
dc.publisherPortland Press Ltden
dc.relation.ispartofClinical Scienceen
dc.titleEffect of training on the response of plasma vascular endothelial growth factor to exercise in patients with peripheral arterial diseaseen
dc.typeJournal Articleen
dc.identifier.doi10.1042/CS20060151en
dc.subject.keywordsCardiology (incl Cardiovascular Diseases)en
local.contributor.firstnameREen
local.contributor.firstnameBEen
local.contributor.firstnameCDen
local.contributor.firstnamePJen
local.contributor.firstnameSimonen
local.contributor.firstnameIBen
local.subject.for2008110201 Cardiology (incl Cardiovascular Diseases)en
local.subject.seo2008970116 Expanding Knowledge through Studies of Human Societyen
local.profile.schoolSchool of Science and Technologyen
local.profile.emailsgreen23@une.edu.auen
local.output.categoryC1en
local.record.placeauen
local.record.institutionUniversity of New Englanden
local.identifier.epublicationsrecordpes:4356en
local.publisher.placeLondon, United Kingdomen
local.format.startpage401en
local.format.endpage409en
local.peerreviewedYesen
local.identifier.volume111en
local.identifier.issue6en
local.contributor.lastnameWooden
local.contributor.lastnameSandersonen
local.contributor.lastnameAskewen
local.contributor.lastnameWalkeren
local.contributor.lastnameGreenen
local.contributor.lastnameStewarten
dc.identifier.staffune-id:sgreen23en
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.identifier.unepublicationidune:8763en
dc.identifier.academiclevelAcademicen
local.title.maintitleEffect of training on the response of plasma vascular endothelial growth factor to exercise in patients with peripheral arterial diseaseen
local.output.categorydescriptionC1 Refereed Article in a Scholarly Journalen
local.description.statisticsepubsVisitors: 203<br />Views: 203<br />Downloads: 0en
local.search.authorWood, REen
local.search.authorSanderson, BEen
local.search.authorAskew, CDen
local.search.authorWalker, PJen
local.search.authorGreen, Simonen
local.search.authorStewart, IBen
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