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Title: Analysis of collagen fibre shape changes in breast cancer
Contributor(s): Murison, Robert David  (author); Falzon, Gregory  (author)orcid ; Pearson, Sarah Jayne (author)
Publication Date: 2008
DOI: 10.1088/0031-9155/53/23/001
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Abstract: Second harmonic generation microscopy was performed on both normal and diseased breast tissue. Differences in the collagen fibre shape between normal, benign and malignant breast tissue were compared and quantified using elliptical Fourier analysis. Principal shape analysis of these coefficients provided an understanding of the key differences in collagen fibre shape between the three tissue types. A Gaussian model was also used to associate the shape of the fibre with the probability that it had been sampled from malignant breast tissue. These results provide quantitative evidence for the alteration of collagen fibre shape in both benign and malignant breast tissue.
Publication Type: Journal Article
Source of Publication: Physics in Medicine and Biology, 53(23), p. 6641-6652
Publisher: Institute of Physics Publishing
Place of Publication: Bristol, United Kingdom
ISSN: 1361-6560
Field of Research (FOR): 010202 Biological Mathematics
Socio-Economic Outcome Codes: 920102 Cancer and Related Disorders
Peer Reviewed: Yes
HERDC Category Description: C1 Refereed Article in a Scholarly Journal
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