Analysis of collagen fibre shape changes in breast cancer

Title
Analysis of collagen fibre shape changes in breast cancer
Publication Date
2008
Author(s)
Murison, Robert David
Falzon, Gregory
( author )
OrcID: https://orcid.org/0000-0002-1989-9357
Email: gfalzon2@une.edu.au
UNE Id une-id:gfalzon2
Pearson, Sarah Jayne
Type of document
Journal Article
Language
en
Entity Type
Publication
Publisher
Institute of Physics Publishing Ltd
Place of publication
United Kingdom
DOI
10.1088/0031-9155/53/23/001
UNE publication id
une:8671
Abstract
Second harmonic generation microscopy was performed on both normal and diseased breast tissue. Differences in the collagen fibre shape between normal, benign and malignant breast tissue were compared and quantified using elliptical Fourier analysis. Principal shape analysis of these coefficients provided an understanding of the key differences in collagen fibre shape between the three tissue types. A Gaussian model was also used to associate the shape of the fibre with the probability that it had been sampled from malignant breast tissue. These results provide quantitative evidence for the alteration of collagen fibre shape in both benign and malignant breast tissue.
Link
Citation
Physics in Medicine and Biology, 53(23), p. 6641-6652
ISSN
1361-6560
0031-9155
Start page
6641
End page
6652

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