Please use this identifier to cite or link to this item: https://hdl.handle.net/1959.11/8487
Title: Skeletal muscle phenotype is associated with exercise tolerance in patients with peripheral arterial disease
Contributor(s): Askew, CD (author); Green, Simon (author); Walker, PJ (author); Kerr, GK (author); Green, AA (author); Williams, AD (author); Febbraio, MA (author)
Publication Date: 2005
DOI: 10.1016/j.jvs.2005.01.037
Handle Link: https://hdl.handle.net/1959.11/8487
Abstract: Objective: To better understand the association between skeletal muscle and exercise intolerance in peripheral arterial disease (PAD), we assessed treadmill-walking performance and gastrocnemius muscle phenotype in healthy control subjects and in patients with PAD. We hypothesized that gastrocnemius muscle characteristics would be altered in PAD compared with control subjects and that exercise tolerance in patients PAD would be related to muscle phenotype. Methods: Sixteen patients with PAD and intermittent claudication and 13 healthy controls of the same age participated. Each subject completed a graded treadmill-walking test and underwent a resting muscle biopsy. Muscle biopsy samples were obtained from the medial gastrocnemius muscle of the most ischemic limb in PAD and a limb chosen at random in controls. Samples were analyzed for fiber type and cross-sectional area, capillary-to-fiber ratio, the number of capillaries in contact with each fiber type, and the optical density of glycogen within each fiber by using histochemical procedures. Total muscle glycogen content was determined biochemically. Results: Exercise capacity measured on the incremental walking test in the PAD group was only 30% to 40% of that observed in controls. The PAD group had a lower proportion of type I muscle fibers (P < .05), fewer capillaries per muscle fiber (P < .05), and tended to have smaller fiber areas (P = .08). The relative area of type I fibers, the capillary-to-fiber ratio, capillary contacts with type I and IIa fibers, and the optical density of glycogen in type I fibers were all positively correlated with exercise tolerance in the PAD group(P < .05) but not controls. Conclusions: These data suggest that muscle phenotype is altered in PAD and that such alterations are associated with the exercise intolerance in these patients. In light of these findings, therapies such as resistance training or electrical stimulation that target skeletal muscle in PAD may prove beneficial, and further investigation of such therapies is warranted.
Publication Type: Journal Article
Source of Publication: Journal of Vascular Surgery, 41(5), p. 802-807
Publisher: Mosby, Inc
Place of Publication: United States of America
ISSN: 1097-6809
0741-5214
Fields of Research (FoR) 2008: 110201 Cardiology (incl Cardiovascular Diseases)
Socio-Economic Objective (SEO) 2008: 920103 Cardiovascular System and Diseases
Peer Reviewed: Yes
HERDC Category Description: C1 Refereed Article in a Scholarly Journal
Appears in Collections:Journal Article

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