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Title: Altered lymphocyte heat shock protein 70 expression in patients with HIV disease
Contributor(s): Agnew, L  (author)orcid ; Kelly, M (author); Howard, J (author); Jeganathan, S (author); Batterham, M (author); Ffrench, R (author); Gold, J (author); Watson, K  (author)
Publication Date: 2003
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Abstract: Heat shock protein (HSP) expression in lymphocytesisolated from 20 patients with HIV diseaseand 15 age-matched controls was determined.Fold increases in lymphocyte hsp70 expressionafter heat shock were 4.52 ± 2.97 in HIV-positiveindividuals compared with 2.60 ± 1.29 for HIV-negativecontrols (P = 0.001). Given clear rolesfor HSP in the cross-presentation of antigens, α-defensininternalization and pro-inflammatorycytokine production, a further investigation ofHSP in HIV patients is merited.
Publication Type: Journal Article
Source of Publication: AIDS: Research Letters, 17(13), p. 1985-1988
Publisher: Lippincott Williams & Wilkins
Place of Publication: Philadelphia, USA
ISSN: 0269-9370
Field of Research (FOR): 110704 Cellular Immunology
Peer Reviewed: Yes
HERDC Category Description: C1 Refereed Article in a Scholarly Journal
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Appears in Collections:Journal Article
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