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https://hdl.handle.net/1959.11/8328
Title: | Blood concentrations of omega-3 in participants with juvenile bipolar disorder compared to healthy controls | Contributor(s): | Clayton, EH (author); Hanstock, Tanya (author); Hirneth, SJ (author); Kable, CJ (author); Garg, ML (author); Hazell, PL (author) | Publication Date: | 2008 | Handle Link: | https://hdl.handle.net/1959.11/8328 | Related DOI: | 10.1080/00048670802549638 | Abstract: | Background: A deficiency of long-chain omega-3 polyunsaturated fatty acids (LCn-3PUFA), including eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), has been reported in adults with depression and bipolar disorder (BD). Aims: To examine LCn-3PUFA status in children and adolescents with juvenile BD (JBD) compared to healthy controls and the relationship with symptoms of mania and depression. Method: Fifteen participants (9-18 yrs) with JBD and fifteen age and sex-matched controls were assessed for dietary intake and red blood cell (RBC) LCn-3PUFA. Results: RBC EPA and DHA were significantly lower in participants with JBD compared to controls, but not after controlling for LCn-3PUFA intake. RBC DHA was also negatively related to clinician ratings of depression and participant ratings of aggression. Conclusion: Lower RBC LCn-3PUFA in JBD was explained by lower intakes in the current study. Given previous evidence linking deficiencies of LCn-3PUFA to BD, a randomised placebo-controlled study examining supplementation with LCn-3PUFA as an adjunct to standard pharmacotherapy appears warranted in this participant population. | Publication Type: | Journal Article | Source of Publication: | Australian & New Zealand Journal of Psychiatry, 42(Supplement 3), p. A45-A45 | Publisher: | Sage Publications Ltd | Place of Publication: | United Kingdom | ISSN: | 1440-1614 0004-8674 |
Fields of Research (FoR) 2008: | 170106 Health, Clinical and Counselling Psychology | Socio-Economic Objective (SEO) 2008: | 920410 Mental Health | HERDC Category Description: | C4 Letter of Note |
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Appears in Collections: | Journal Article |
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