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Title: Long chain omega-3 polyunsaturated fatty acids in the treatment of psychiatric illnesses in children and adolescents
Contributor(s): Clayton, EH (author); Hanstock, Tanya (author); Garg, ML (author); Hazell, PL (author)
Publication Date: 2007
DOI: 10.1111/j.1601-5215.2007.00189.x
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Abstract: Objective:  Long chain omega-3 polyunsaturated fatty acids (LCn-3PUFA) are in increasing use in the general population to treat health problems. The objective of the current article is to review the evidence for the rationale and benefit of LCn-3PUFA in the treatment of common psychiatric disorders in children and adolescents. Methods:  A search of Psychlit, PubMed and Cochrane Databases was conducted using the terms child, adolescent, bipolar, depression, psychosis, first-episode psychosis, schizophrenia, attention deficit hyperactivity disorder (ADHD), autism, psychiatric, omega-3, n-3, docosahexaenoic acid and eicosapentaenoic acid. Further studies were identified from the bibliographies of published reviews. Results:  One small randomized controlled trial with LCn-3PUFA supplementation in depression in children found a small beneficial effect over placebo. Four placebo-controlled trials showed uncertain benefit of LCn-3PUFA for ADHD. Single placebo-controlled trials showed no benefit in autism or bipolar disorder. There is an absence of studies examining benefit for first-episode psychosis or schizophrenia in children and adolescents. Conclusions:  While children and adolescents are receiving LCn-3PUFA for a range of psychiatric indications, there is only evidence of likely benefit for unipolar depression.
Publication Type: Journal Article
Source of Publication: Acta Neuropsychiatrica, 19(2), p. 92-103
Publisher: Wiley-Blackwell Publishing Inc
Place of Publication: United States of America
ISSN: 1601-5215
Field of Research (FOR): 170106 Health, Clinical and Counselling Psychology
Socio-Economic Outcome Codes: 920410 Mental Health
920411 Nutrition
Peer Reviewed: Yes
HERDC Category Description: C1 Refereed Article in a Scholarly Journal
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