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https://hdl.handle.net/1959.11/8310
Title: | Reduced mania and depression in juvenile bipolar disorder associated with long-chain w-3 polyunsaturated fatty acid supplementation | Contributor(s): | Clayton, EH (author); Hanstock, Tanya (author); Hirneth, SJ (author); Kable, CJ (author); Garg, ML (author); Hazell, PL (author) | Publication Date: | 2009 | DOI: | 10.1038/ejcn.2008.81 | Handle Link: | https://hdl.handle.net/1959.11/8310 | Abstract: | Long-chain ω-3 polyunsaturated fatty acid (LCn-3PUFA) supplementation may improve symptoms of depression in children and bipolar disorder (BD) in adults. No studies have examined the effectiveness of LCn-3PUFA supplementation in the treatment of mania and depression in juvenile BD (JBD) when given as an adjunct to standard pharmacological treatment. Eighteen children and adolescents with JBD received supplements containing 360 mg per day eicosapentaenoic acid (EPA) and 1560 mg per day docosahexaenoic acid (DHA) for 6 weeks in an open-label study. Intake and fasting red blood cell (RBC) LCn-3PUFA, mania, depression and global function were assessed before and after supplementation. RBC EPA and DHA were significantly higher following supplementation. Clinician ratings of mania and depression were significantly lower and global functioning significantly higher after supplementation. Parent ratings of internalizing and externalizing behaviours were also significantly lower following supplementation. A larger randomized controlled trial appears warranted in this participant population. | Publication Type: | Journal Article | Source of Publication: | European Journal of Clinical Nutrition, 63(8), p. 1037-1040 | Publisher: | Nature Publishing Group | Place of Publication: | United Kingdom | ISSN: | 1476-5640 0954-3007 |
Fields of Research (FoR) 2008: | 170106 Health, Clinical and Counselling Psychology | Socio-Economic Objective (SEO) 2008: | 920410 Mental Health 920411 Nutrition |
Peer Reviewed: | Yes | HERDC Category Description: | C1 Refereed Article in a Scholarly Journal |
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Appears in Collections: | Journal Article |
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