Please use this identifier to cite or link to this item: https://hdl.handle.net/1959.11/8310
Title: Reduced mania and depression in juvenile bipolar disorder associated with long-chain w-3 polyunsaturated fatty acid supplementation
Contributor(s): Clayton, EH (author); Hanstock, Tanya (author); Hirneth, SJ (author); Kable, CJ (author); Garg, ML (author); Hazell, PL (author)
Publication Date: 2009
DOI: 10.1038/ejcn.2008.81
Handle Link: https://hdl.handle.net/1959.11/8310
Abstract: Long-chain ω-3 polyunsaturated fatty acid (LCn-3PUFA) supplementation may improve symptoms of depression in children and bipolar disorder (BD) in adults. No studies have examined the effectiveness of LCn-3PUFA supplementation in the treatment of mania and depression in juvenile BD (JBD) when given as an adjunct to standard pharmacological treatment. Eighteen children and adolescents with JBD received supplements containing 360 mg per day eicosapentaenoic acid (EPA) and 1560 mg per day docosahexaenoic acid (DHA) for 6 weeks in an open-label study. Intake and fasting red blood cell (RBC) LCn-3PUFA, mania, depression and global function were assessed before and after supplementation. RBC EPA and DHA were significantly higher following supplementation. Clinician ratings of mania and depression were significantly lower and global functioning significantly higher after supplementation. Parent ratings of internalizing and externalizing behaviours were also significantly lower following supplementation. A larger randomized controlled trial appears warranted in this participant population.
Publication Type: Journal Article
Source of Publication: European Journal of Clinical Nutrition, 63(8), p. 1037-1040
Publisher: Nature Publishing Group
Place of Publication: United Kingdom
ISSN: 1476-5640
0954-3007
Field of Research (FOR): 170106 Health, Clinical and Counselling Psychology
Socio-Economic Outcome Codes: 920410 Mental Health
920411 Nutrition
Peer Reviewed: Yes
HERDC Category Description: C1 Refereed Article in a Scholarly Journal
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