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https://hdl.handle.net/1959.11/8241
Title: | Association of Inherited Thrombophilia with Recurrent Pregnancy Loss in Palestinian Women | Contributor(s): | Abu-Asab, Nihad (author); Ayesh, Suhail K (author); Ateeq, Rwan O (author); Nassar, Suhair M (author); El-Sharif, Wassif A (author) | Publication Date: | 2011 | Open Access: | Yes | DOI: | 10.1155/2011/689684 | Handle Link: | https://hdl.handle.net/1959.11/8241 | Abstract: | Objective: This study aimed at analyzing the association between recurrent pregnancy loss (RPL) and factor V G1691A (FVL), prothrombin G20210 (FII); and MTHFR C677T (MTHFR) in Palestinian women. Method: We studied 329 Palestinian women with RPL and/or stillbirth (SB); and compared them to 402 healthy reproductive Palestinian women. Cases and controls were tested for the above mutations. Odds ratio (OR) at confidence interval (CI) of 95% was used as a measure of association between the mutations and RPL. Results: Our statistical analysis showed a slightly increased association, which was not significant between FVL and RPL (OR 1.32, 95% CI 0.90–1.94), and no association between FII (OR 0.84, 95% CI 0.38–1.92), MTHFR (OR 0.58, 95% CI 0.32–1.03), and RPL. Further analysis of RPL subgroups revealed an association between FVL and first-trimester loss (OR 1.33, 95% CI 0.892–1.989), and second-trimester loss (OR 1.13, 95% CI 0.480–2.426), both were not statistically significant. Furthermore, the only statistically significant association was between FVL and SB (OR 2.0, 95% CI 1.05–3.70). Conclusion: Our analysis had failed to find a significant association between FVL, FII, MTHFR; and RPL in either the first or second trimester. FVL was significantly associated with fetal loss if the loss was a stillbirth. | Publication Type: | Journal Article | Source of Publication: | Obstetrics and Gynecology International | Publisher: | Hindawi Publishing Corporation | Place of Publication: | United States of America | ISSN: | 1687-9597 1687-9589 |
Fields of Research (FoR) 2008: | 110399 Clinical Sciences not elsewhere classified 111402 Obstetrics and Gynaecology 111404 Reproduction |
Socio-Economic Objective (SEO) 2008: | 920499 Public Health (excl. Specific Population Health) not elsewhere classified 920101 Blood Disorders |
Peer Reviewed: | Yes | HERDC Category Description: | C1 Refereed Article in a Scholarly Journal |
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Appears in Collections: | Journal Article |
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